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Physical & Chemical properties

Water solubility

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Endpoint:
water solubility
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
supporting study
Study period:
13-Jun-2012 to 16-Jun-2012
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
comparable to guideline study
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
GLP compliance:
not specified
Type of method:
column elution method
Water solubility:
< 0.05 mg/L
Temp.:
20 °C

Results

 

Flow rate (ml/h)

Fraction No.

Stearyl Erucamide

pH value

25.0

1 (1-2)

< 0.05

6.4

 

2 (3-4)

< 0.05

6.3

 

3 (5-6)

< 0.05

6.3

 

4 (7-8)

< 0.05

6.3

 

5 (9-10)

< 0.05

6.3

 

6 (11-12)

< 0.05

6.2

 

7 (13-14)

< 0.05

6.3

 

8 (15-16)

< 0.05

6.3

 

 

 

 

12.5

1 (1-2)

< 0.05

6.0

 

2 (3-4)

< 0.05

6.1

 

3 (5-6)

< 0.05

6.2

 

4 (7-8)

< 0.05

6.2

 

5 (9-10)

< 0.05

6.1

 

6 (11-12)

< 0.05

6.1

 

7 (13-14)

< 0.05

6.1

 

8 (15-16)

< 0.05

6.2

 

 

Thus, the following value for water solubility of the test item Stearyl Erucamide can be reported according to test procedure according to EU test method L142A/57-66 (EEC A.6).

 

Water solubility Stearyl Erucamide < 0.05mg/l

 

pH value HPLC water: 6.4

 

The water solubility was determined at 20°C.

Working range

The calibration curve fits over the whole working range from 0.05 to 2.05 mg/L with r2= 1. A quadratic fit was used.

 

Recovery

In the course of the recovery experiment, an average recovery rate of 99% was determined.

Conclusions:
Interpretation of results (migrated information): insoluble (< 0.1 mg/L)
The water solubility of N-octadecyldocos-13-enamide (CAS 10094-45-8; EC 233-226-5) is less than 0.05 mg/L.
Executive summary:

In an EU Method A.6 study, not conducted according to GLP, the water solubility of the structurally similar read across substance is less than 0.05 mg/L.

Endpoint:
water solubility
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
supporting study
Study period:
13-Nov-2012 to 14-Mar-2013
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
comparable to guideline study
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
GLP compliance:
not specified
Type of method:
column elution method
Water solubility:
< 0.01 mg/L
Temp.:
20 °C

Results

  

Flow rate (ml/h)

Fraction No.

Oleyl Palmitamide

pH value

25.0

1 (1-2)

< 0.01

6.7

 

2 (3-4)

< 0.01

6.7

 

3 (5-6)

< 0.01

6.8

 

4 (7-8)

< 0.01

6.8

 

5 (9-10)

< 0.01

6.8

 

6 (11-12)

< 0.01

6.8

 

7 (13-14)

< 0.01

6.8

 

8 (15-16)

< 0.01

6.8

 

 

 

 

12.5

1 (1-2)

< 0.01

6.7

 

2 (3-4)

< 0.01

6.7

 

3 (5-6)

< 0.01

6.7

 

4 (7-8)

< 0.01

6.7

 

5 (9-10)

< 0.01

6.7

 

6 (11-12)

< 0.01

6.7

 

7 (13-14)

< 0.01

6.7

 

8 (15-16)

< 0.01

6.7

 

 

Thus, the following value for water solubility of the test item Oleyl Palmitamide can be reported according to test procedure according to EU test method L142A/57-66 (EEC A.6).

 

Water solubility Oleyl Palmitamide < 0.01mg/l

 

pH value HPLC water: 6.6

The water solubility was determined at 20°C

Working range

The calibration curve fits over the whole working range from 0.01 to 2.06 mg/L with r2= 1. A quadratic fit was used.

 

Recovery

In the course of the recovery experiment, an average recovery rate of 117% was determined.

Conclusions:
Interpretation of results (migrated information): insoluble (< 0.1 mg/L)
The water solubility of Oleyl Palmitamide CAS 16260-09-6 EC 240-367-6 is less than 0.01 mg/L.
Executive summary:

In an EU Method A.6 study, not conducted according to GLP, the water solubility of the structurally similar read across substance is less than 0.01 mg/L.

Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
July 2013
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
flask method
Water solubility:
< 0.051 mg/L
Temp.:
20 °C
pH:
7

The preliminary water solubility test indicated that the column elution method should have been performed as the solubility was less than 1x10-2g/L. However, due to the extremely low water solubility of the test item, a large volume of sample was required for the analysis. This made determination by the column elution method impractical due to the extremely large reservoir volume which would be required to facilitate multiple samples to be taken. Therefore the flask method was used as this allowed for larger sample volumes to be taken for analysis

Conclusions:
Interpretation of results (migrated information): insoluble (< 0.1 mg/L)
The water solubility of the test material is less than 5.06 x 10-5 g/L of solution at 20.0 ± 0.5 °C.
Executive summary:

In an OECD 105 study, conducted according to GLP, the water solubility of the test material is less than 0.0506 mg/L, and is therefore considered insoluble in water.

Description of key information

Key Study:

In an OECD 105 study, conducted according to GLP, the water solubility of the test material is less than 0.0506 mg/L, and is therefore considered insoluble in water.

 

Supporting Studies:

In an EU Method A.6 study, not conducted according to GLP, the water solubility of the structurally similar read across substance is less than 0.01 mg/L.

In an EU Method A.6 study, not conducted according to GLP, the water solubility of the structurally similar read across substance is less than 0.05 mg/L.

Key value for chemical safety assessment

Water solubility:
0.051 mg/L
at the temperature of:
20 °C

Additional information