2-(4-benzylpiperazin-1-yl)-6,7-dimethoxyquinazolin-4-amine hydrochloride

Guidance on Safe Use

First-aid measures

General advice: Consult a physician. Show this safety data sheet to the doctor in attendance.

If inhaled: If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.

In case of skin contact: Wash off with soap and plenty of water. Consult a physician.

In case of eye contact:Flush eyes with water as a precaution.

If swallowed: Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

Fire-fighting measures

Suitable extinguishing media: Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

Special hazards arising from the substance or mixture: No data available

Advice for firefighters: Wear self - contained breathing apparatus for firefighting if necessary.

Accidental release measures

Personal precautions, protective equipment and emergency procedures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Avoid breathing dust.

Personal protective equipment:

Eye/face protection:Safety glasses with side-shields conforming to EN166 Use equipment for eye protection tested  and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection: Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique  (without touching glove's outer surface) to avoid skin contact with this product. Dispose of  contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and

the standard EN 374 derived from it.

Body Protection: Complete suit protecting against chemicals, The type of p rotective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.

Respiratory protection: For nuisance exposures use type P95 (US) or type P1 (EU EN 143) particle respirator.For higher level protection use type OV/AG/P99 (US) or type ABEK - P2 (EU EN 143) respirator cartridges. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).

Handling and storage

Precautions for safe handling: Avoid contact with skin and eyes. Avoid formation of dust and aerosols.Provide appropriate exhaust ventilation at places where dust is formed.Normal measures for preventive fire protection.

Conditions for safe storage, including any incompatibilities: Store in cool place.Keep container tightly closed in a dry and well-ventilated place.

Transport information

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Marine transport (UN RTDG/IMDG)

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Exposure controls / personal protection

Normal operation

Workers use PPE as a good practice to minimise possible exposures from minor accidental leaks during loading and unloading the reaction vessel, even though rigorous containment is ensured through technical means. Procedures are in place for disposal or cleaning of contaminated PPE.

Accident and incidents

A fully trained Emergency Response Team (ERT) is in place to react in case of accidents and incidents resulting in unexpected releases of the intermediate in order to minimize risks of exposures to humans and the environment. Components of the ERT are selected among senior site operators and technicians and are periodically trained and certified to respond to emergencies. Trainings and certifications of members ERT are subject to periodical revisions and approval by Local Fire Department. PPE as specified in emergency procedures and training are required in case of accidents and incidents. Procedures are in place for disposal or cleaning of contaminated PPE, as appropriate.

Maintenance and cleaning

Workers use additional PPE for cleaning the reaction vessel. A short exposure may occur during a maintenance operation, involving opening of a section of the pipeline connecting the reactor with loading station due to accidental presence of a residue of diluted intermediate that may lead to skin exposure. As a result, workers are given a specific work instruction on how to open this section, and are required to use high-efficiency PPE for skin and respiratory protection, as a precautionary and protective measure during all maintenance work, where there is a potential for exposure. PPE type is specified in the permit-to-work documents. Procedures are in place for disposal or cleaning of contaminated PPE, as appropriate.