Registration Dossier
Registration Dossier
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EC number: 610-623-5 | CAS number: 511540-64-0
Adsorption / desorption
Administrative data
Link to relevant study record(s)
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 28 Oct - 2 Dec 2015
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.19 (Estimation of the Adsorption Coefficient (KOC) on Soil and Sewage Sludge Using High Performance Liquid Chromatography (HPLC))
- GLP compliance:
- yes
- Type of method:
- HPLC estimation method
- Media:
- other: calibration of HPLC column using standards
- Radiolabelling:
- no
- Test temperature:
- 25 °C
- Details on study design: HPLC method:
- EQUIPMENT
- HPLC with variable wavelength,
- column: LiChrospher 100 CN
- column temperature 25 °C
MOBILE PHASES
- Type: Methaol/distilled water, pH 6.9, isocratic elution
DETERMINATION OF DEAD TIME
- Method: by means of homologous series / by inert substances which are not retained by the column
REFERENCE SUBSTANCES
- Acetanilide, CAS 103-84-4, Purity 99.8 %
- Atrazine, CAS 1912-24-9, Purity 99.1 %
- Triadimenol, CAS 55219-24-9, Purity 98.7 %
- Linuron, CAS 330-55-2, Purity 99.7 %
- Pyrazophos, CAS 13457-18-6, Purity 99.8 %
- Diclofop-methyl, CAS 51338-27-3, Purity 99.1 %
- 4,4'-DDT, CAS 50-29-3, Purity 99.8 %
REPETITIONS
- Number of determinations: 2
EVALUATION
- Calculation of capacity factors k': according to OECD TG 121
- Determination of the log Koc value: according to OECD TG 121 - Sample No.:
- #1
- Type:
- log Koc
- Value:
- 5.1 dimensionless
- pH:
- 6
- Temp.:
- 25 °C
- Sample No.:
- #2
- Type:
- log Koc
- Value:
- 5.11 dimensionless
- pH:
- 6
- Temp.:
- 25 °C
- Key result
- Type:
- log Koc
- Value:
- 5.1 dimensionless
- pH:
- 6
- Temp.:
- 25 °C
- Key result
- Type:
- Koc
- Value:
- 128 825 L/kg
- pH:
- 6
- Temp.:
- 25 °C
- Details on results (HPLC method):
- For Retention times of reference substances used for calibration and average retention data for test substance, please refer to any other information on results, incl. tables and figures
- Validity criteria fulfilled:
- yes
- Conclusions:
- The adsorption coefficient of the test item was determined acc. to the HPLC method described in OECD guideline 121. The adsorption coefficient of the test item was found to be log Koc = 5.1.
- Executive summary:
The adsorption/desorption of the test item was determined according to EU-method C.19 and OECD 121 using the HPLC method. The retention time of the test item was compared with a calibration/regression curve obtained by the measurement of 7 standard chemicals. The retention time of the test item was approx. 15.8 min. Comparing with the regression, a log Koc of 5.1 was calculated.
Reference
Table 1: Measured data of calibration substances and test item
| Substance (calibration substance or test item) | 1st inj. retantion time/min | k | log k | log Koc |
| 1st measurement | ||||
| Acetanilide | 2.16 | 0.28 | -0.55 | 1.25 |
| Atrazine | 2.42 | 0.44 | -0.36 | 1.81 |
| Triadimenol | 3.15 | 0.87 | -0.06 | 2.40 |
| Linuron | 3.46 | 1.05 | 0.02 | 2.59 |
| Pyrazophos | 5.44 | 2.23 | 0.35 | 3.65 |
| Diclofop-methyl | 7.82 | 3.64 | 0.56 | 4.20 |
| 4,4'-DDT | 23.84 | 13.15 | 1.12 | 5.63 |
| 2nd measurement | ||||
Acetanilide |
2.16 |
0.28 |
-0.55 |
1.25 |
Atrazine |
2.44 |
0.45 |
-0.35 |
1.81 |
Triadimenol |
3.15 |
0.87 |
-0.06 |
2.40 |
Linuron |
3.47 |
1.06 |
0.02 |
2.59 |
Pyrazophos |
5.43 |
2.22 |
0.35 |
3.65 |
Diclofop-methyl |
7.83 |
3.65 |
0.56 |
4.20 |
4,4'-DDT |
23.95 |
13.22 |
1.12 |
5.63 |
| Test item | ||||
| 1st measurement | 15.80 | 8.38 | 0.92 | 5.11 |
| 2nd measurement | 15.73 | 8.34 | 0.92 | 5.10 |
Regression: log Koc = a + b x log k
Parameters:
1st measurement: a = 2.67, b = 2.64, r² = 0.997
2nd measurement: a = 2.66, b = 2.65, r² = 0.997
Table 2: Determination of the dead time
Dead time marker |
retention time (1st measurement)/min |
retention time (2nd measurement)/min |
retention time (mean)/min |
Formamide |
1.69 |
1.68 |
1.69 |
Description of key information
The adsorption coefficient of the test item was determined acc. to the HPLC method described in OECD Guideline 121. The adsorption coefficient of the test item was found to be log Koc = 5.1, which relates to a Koc value of 128825.
Key value for chemical safety assessment
- Koc at 20 °C:
- 128 825
Additional information
The adsorption/desorption of the test item was determined according to EU-method C.19 and OECD 121 using the HPLC method. The retention time of the test item was compared with a calibration/regression curve obtained by the measurement of 7 standard chemicals. The retention time of the test item was approx. 15.8 min. Comparing with the regression, a log Koc of 5.1 was calculated.
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