Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
other: collection of data
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data

Data source

Reference
Reference Type:
review article or handbook
Title:
SIDS INITIAL ASSESSMENT PROFILE - Aliphatic Secondary Amines
Author:
OECD
Year:
2013

Materials and methods

GLP compliance:
not specified

Test animals

Species:
rabbit

Results and discussion

Applicant's summary and conclusion

Interpretation of results:
Category 1 (corrosive) based on GHS criteria
Conclusions:
All members of the aliphatic secondary amine category are corrosive to the skin (rabbits, primarily in Draize tests or similar to OECD TG 404). No eye irritation data are available for DIBA and DPeA. Based on the available data for the remaining category members (rabbit, no guideline specified or similar to OECD TG 405) and known eye irritation potential of alkyl amines in general, it is expected that all the amines in the category are corrosive to the eye.