Registration Dossier
Registration Dossier
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EC number: - | CAS number: -
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Key result
- Type:
- log Pow
- Partition coefficient:
- > 6
- Temp.:
- 25 °C
- Remarks on result:
- other: pH not relevant
- Type:
- log Pow
- Partition coefficient:
- 12.3
- Remarks on result:
- other: calculated value for the main component (US EPA KOWWIN QSAR model v1.68, 2010)
- Details on results:
- There were no significant peaks present in the sample chromatogram before the retention time of DDT, the highest available reference standard with a known log10Pow value of 6.2. The components of the reference mixture eluted in the order of their known log10Pow values, the earliest eluting component being the deadtime standard, formamide. It was thus considered either that the method was inapplicable due to the components of the test substance being too insoluble for detection, or that any soluble components of the test substance eluted after DDT (or did not elute under the conditions of the analysis). The test substance components are, therefore, reported as having log10Pow values in excess of 6.
This conclusion is consistent with the value of log10Pow for representative components of the test material estimated by a calculation method using a computer program (KOWWIN, Version 1.68, U.S. Environmental Protection Agency, 2000). A log10Pow of 12.3 was calculated for the main component of the test material. Similar values (12.1-13.4) were calculated for the other components.
Reference
Description of key information
Log Pow >6 at 25°C (OECD 117, EU A8)
Log Pow = 12 (KOWWIN v1.68, 2010)
Key value for chemical safety assessment
Additional information
Computer modelling (US EPA KOWWIN QSAR model v1.68, 2010) indicated a Log Pow of 12.3 for the main component of the test material. Similar values (12.1 -13.4) were calculated for the other components.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
