2-hydroxy-N-1H-1,2,4-triazol-3-ylbenzamide

Water solubility

Administrative data

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

26 June 2018 - 13 July 2018

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2018

Report date:

2018

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Test guideline 2

Qualifier:

according to guideline

Guideline:

EU Method A.6 (Water Solubility)

GLP compliance:

yes (incl. QA statement)

Type of method:

column elution method

Test material

Test material information

Constituent 1

Reference substance name:

2-hydroxy-N-1H-1,2,4-triazol-3-ylbenzamide

EC Number:

253-021-4

EC Name:

2-hydroxy-N-1H-1,2,4-triazol-3-ylbenzamide

Cas Number:

36411-52-6

Molecular formula:

C9H8N4O2

IUPAC Name:

2-hydroxy-N-1H-1,2,4-triazol-3-ylbenzamide

Test material form:

solid: particulate/powder

Details on test material:

Batch:102Z5
Purity: 99.9%
white powder

Specific details on test material used for the study:

Batch: 102Z5
Purity: 99.9%

Results and discussion

Water solubility

Key result

Water solubility:

ca. 0.004 g/L

Conc. based on:

test mat.

Loading of aqueous phase:

0.102 g/L

Incubation duration:

ca. 125 h

Temp.:

20 °C

pH:

>= 6.2 - <= 6.3

Details on results:

See Table 1

Any other information on results incl. tables

Table 1. Overall results of water solubility

System	Mean Concentration (g/L)	Standard Deviation
A	4.63 x 10e-3	1.43 x 10e-4
B	4.24 x 10e-3	6.35 x 10e-5

Applicant's summary and conclusion

Conclusions:

The water solubility of the test item has been determined to be 4.44 x 10e-3 g/L of solution at 20.0 ± 0.5 °C.