Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
boiling point
Type of information:
experimental study
Adequacy of study:
key study
Study period:
Aug - Dec 2018
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2013
Report date:
2013

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
OECD Guideline 103 (Boiling Point)
Qualifier:
according to guideline
Guideline:
EPA OPPTS 830.7220 (Boiling Point / Boiling Range)
Qualifier:
according to guideline
Guideline:
EU Method A.2 (Boiling Temperature)
GLP compliance:
yes
Type of method:
differential scanning calorimetry

Test material

Constituent 1
Chemical structure
Reference substance name:
2-Fluoro-4-[7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]benzoic acid—hydrogen chloride (1/2)
Cas Number:
1197377-34-6
Molecular formula:
C22H14FN5O2•2 HCl
IUPAC Name:
2-Fluoro-4-[7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]benzoic acid—hydrogen chloride (1/2)
Test material form:
solid: particulate/powder

Results and discussion

Boiling point
Key result
Atm. press.:
ca. 1 013.25 hPa
Decomposition:
yes
Decomp. temp.:
> 200 °C

Applicant's summary and conclusion

Conclusions:
The melting and boiling temperature of INC280-B4 were determined using DSC.
Reaction and/or decomposition of the test substance was observed at temperatures of >200°C (>473K). Melting and/or boiling of the test substance was not observed below the temperature at which reaction and/or decomposition started. Based on this, the test substance has no melting and/or boiling temperature.