Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
Aug - Dec 2013
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2013
Report date:
2013

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Qualifier:
according to guideline
Guideline:
EPA OPPTS 830.7840 (Water Solubility)
GLP compliance:
yes
Type of method:
column elution method

Test material

Constituent 1
Chemical structure
Reference substance name:
2-Fluoro-4-[7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]benzoic acid—hydrogen chloride (1/2)
Cas Number:
1197377-34-6
Molecular formula:
C22H14FN5O2•2 HCl
IUPAC Name:
2-Fluoro-4-[7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]benzoic acid—hydrogen chloride (1/2)
Test material form:
solid: particulate/powder

Results and discussion

Water solubility
Key result
Water solubility:
ca. 4.35 mg/L
Conc. based on:
test mat.
Temp.:
20 °C
pH:
ca. 7.1

Applicant's summary and conclusion

Conclusions:
The column elution method was applied for the determination of the water solubility of INC280-B4.
The water solubility of the test substance at 20°C was 4.35 mg/l.
The pH of the aqueous samples was 7.1.