Registration Dossier
Registration Dossier
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EC number: 500-332-0 | CAS number: 153195-44-9
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- June 2017 - March 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient - HPLC Method)
- Deviations:
- not specified
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Deviations:
- not specified
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Key result
- Type:
- log Pow
- Partition coefficient:
- 4.06 - 6.5
- Temp.:
- 20 °C
- pH:
- 6.7
- Remarks on result:
- other: log10 Pow in the range 4.06 to greater than 6.5.
- Conclusions:
- The partition coefficient of the test item at pH 6.7 has been determined to be in the range 1.16 x 104 to greater than 3.2 x 106, log10 Pow in the range 4.06 to greater than 6.5.
- Executive summary:
Partition Coefficient (n-Octanol/Water). In the range 1.16 x 104 to greater than 3.2 x 106,
log10 Pow in the range 4.06 to greater than 6.5, using the HPLC method, designed to be
compatible with Method A.8 Partition Coefficient of Commission Regulation (EC) No
440/2008 of 30 May 2008 and Method 117 of the OECD Guidelines for Testing of
Chemicals, 13 April 2004.
Reference
Description of key information
The partition coefficient of the test item at pH 6.7 has been determined to be in the range 1.16 x 104 to greater than 3.2 x 106, log10 Pow in the range 4.06 to greater than 6.5.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 4.06
- at the temperature of:
- 20 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
