Registration Dossier
Registration Dossier
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EC number: 220-425-7 | CAS number: 2760-98-7
Water solubility
Administrative data
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 14 November 2017 - 13 April 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Cross-reference
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Version / remarks:
- 2016
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- 1995
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7840 (Water Solubility)
- Version / remarks:
- 1998
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- flask method
Test material
- Reference substance name:
- Isophthalohydrazide
- EC Number:
- 220-425-7
- EC Name:
- Isophthalohydrazide
- Cas Number:
- 2760-98-7
- Molecular formula:
- C8H10N4O2
- IUPAC Name:
- isophthalohydrazide
- Test material form:
- solid: particulate/powder
- Details on test material:
- Appearance: White crystal powder
Test item storage: At room temperature
Constituent 1
Results and discussion
Water solubility
- Key result
- Water solubility:
- 4.09 g/L
- Conc. based on:
- test mat.
- Incubation duration:
- >= 24 - <= 72 h
- Temp.:
- 20 °C
- pH:
- >= 5.8 - <= 6
- Details on results:
- - Concentration analysed after 24, 48 and 72 hours of stirring: 4.13 g/L, 4.04 g/L and 4.10 g/L, resp.
- Maximum difference meets the criterion of ≤ 15% (i.e. 2.2%)
- The mean of the three concentrations was reported as the water solubility of the substance.
- No test item was detected in the pretreated sample from the blank.
Applicant's summary and conclusion
- Conclusions:
- The water solubility of the substance at 20°C was determined to be 4.09 g/L.
- Executive summary:
The water solubility of the substance was determined using the flask method, in a GLP study according to EC A.6, OECD 105 and OPPTS 830.7840. Quantification of test item concentrations in the water samples was performed by UPLC-UV. The pH of the aqueous samples at the three sampling points was in the range 5.8 - 6.0. From the measurements obtained after 24, 48 and 72 hours of stirring, the water solubility at 20°C was determined to be 4.09 g/L.
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