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EC number: 246-332-1 | CAS number: 24593-34-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- long-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Remarks:
- GLP guideline study (detailed information in Japanese; basic information in English)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 211 (Daphnia magna Reproduction Test)
- GLP compliance:
- not specified
- Analytical monitoring:
- yes
- Vehicle:
- no
- Test organisms (species):
- Daphnia magna
- Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 21 d
- Hardness:
- Control: 230 to 260 mg/L CaCO3 (measured during exposure period)
Treatments: 230 to 265 mg/L CaCO3 (measured during exposure period) - Test temperature:
- 20 +-1 °C
Control: 19.6 to 20.3 °C (measured during exposure period)
Treatments: 19.8 to 20.3 °C (measured during exposure period) - pH:
- Control: 7.7 to 8.4 (measured during exposure period)
Treatments: 7.4 to 8.5 (measured during exposure period) - Dissolved oxygen:
- Control: 7.7 to 8.8 mg/L (measured during exposure period)
Treatments: 5.5 to 8.8 mg/L (measured during exposure period) - Nominal and measured concentrations:
- nominal: Control, 10.0, 18.0, 32.0, 56.0 and 100 mg/L
measured (Time weighted mean): Control, 10.8, 18.7, 32.8, 57.5 and 102 mg/L (102 to 108 % of nominal) - Details on test conditions:
- TEST SYSTEM
- Test vessel fill volume: 80 mL
- Aeration: no
- No. of organisms per vessel: 1
- No. of vessels per concentration (replicates): 10
- No. of vessels per control (replicates): 10
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: M4 medium according to OECD 211
- Intervals of water quality measurement: measured twice per week and at beginning and at the end of exposure period of 21 days
OTHER TEST CONDITIONS
- Adjustment of pH: information not available in english
- Photoperiod: 16 h light : 8 h darkness
- Light intensity: 800 lux
EFFECT PARAMETERS MEASURED: immobility, reproduction, observed daily
TEST CONCENTRATIONS
- Spacing factor for test concentrations: 1.8 - Key result
- Duration:
- 21 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 18 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- reproduction
- Duration:
- 21 d
- Dose descriptor:
- EC50
- Effect conc.:
- 43.3 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- reproduction
- Validity criteria fulfilled:
- yes
Reference
Description of key information
The chronic 21 -d NOEC based on reproduction for Daphnia magna was determined to be 18.0 mg/L.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 18 mg/L
Additional information
A study on the toxicity of 2-ethylhexanoic acid (CAS 149 -57 -5) towards aquatic invertebrates was conducted. A non-GLP study according to OECD guideline 211 was performed by EKOLAB Environmental Oy on behalf of Finnish Chemicals Oy. Daphnia magna was used as a test organism. After 21 days of exposure a NOEC of 25 mg/L and an EC50 of 75 mg/L were estimated, based on the measured concentration (EKOLAB Environmental Oy, 1997, report no.: E2702). However, in this study data is missing about the purity of the test substance and no sufficient information for the analytical measurements on English is available.
As a key study, under supervision of the Japanese Ministry of the Environment, a chronic test on Daphnia magna was conducted according to OECD 211 under GLP and published in 2002. In opposite to the study with the acid, this study was conducted under GLP and the test concentrations were analytically verified. The test concentrations were analytically verified and deviated less than 20% from the nominal concentrations. Moreover, the study was performed with the salt of the acid (Sodium 2-ethylhexanoate, CAS 19766-89-3) which resembles the acid after neutralization. By that, in this study, the toxicity of the test substance was not influenced by acidic pH effects. Therefore, the study was used as a key study for the assessment of the toxicity of CAS 149-57-5 to aquatic invertebrates.
The test duration was 21 days, the test solutions were renewed two times per week. The NOEC for reproduction was determined to be 18 mg/L (NITE, 2002, report no.: A010465 -3).
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