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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Guideline study obtained through inquiry process; SNIF file obtained from ECHA.

Data source

Reference
Reference Type:
other: SNIF
Title:
Unnamed
Year:
2000

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 403 (Acute Inhalation Toxicity)
Deviations:
yes
Remarks:
Exposure duration: 7 hours
GLP compliance:
yes
Test type:
standard acute method
Limit test:
yes

Test material

Constituent 1
Reference substance name:
Body responsible for the test
IUPAC Name:
Body responsible for the test
Test material form:
other: waxy solid
Details on test material:
Product is a waxy, solid material: Mass median diameter is not clearly defined.

Test animals

Species:
rat
Strain:
not specified
Sex:
male/female

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
whole body
Vehicle:
other: for the product no aerodynamic diameter was used because the substance is a waxy solid.
Details on inhalation exposure:
7 hour exposure, whole body
Analytical verification of test atmosphere concentrations:
not specified
Duration of exposure:
7 h
Concentrations:
0.005 mg/L air ≙ 5 mg/m^3 air
No. of animals per sex per dose:
5
Control animals:
not specified

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LC0
Effect level:
5 mg/m³ air
Based on:
test mat.
Remarks:
applicated concentration probably is the highest concentration which can be prepared (nearly saturated)
Exp. duration:
7 h
Remarks on result:
other: No deaths occurred at this concentration. LC50 > 5 mg/m3
Mortality:
Male: 5 mg/m^3 air; Number of animals: 5; Number of deaths: 0
Female: 5 mg/m^3 air; Number of animals: 5; Number of deaths: 0
Clinical signs:
other: The appearance and the behaviour of the treated animals was not influenced during the 14 days observation period.
Body weight:
The body weight was not influenced.
Gross pathology:
No treatment related effects were observed in none of the organs of the animals which were treated with test substance. A decrease of the somatomotoric activities was observed in the control groups and in the test groups as well. This observation was related to the decreased temperature in the exposure chamber.

Any other information on results incl. tables

Exposure chambers were used.

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: other: EU-GHS
Conclusions:
LC50 (rat) > 5 mg/m^3 air (7h)
Executive summary:

The acute inhalation toxicity of the test substance has been determined in a GLP test with rats according to OECD Guideline No. 403. No deaths occurred at the highest dose tested, so the LC50 value is > 5 mg/m3 air (7h).