Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 268-776-5 | CAS number: 68140-14-7
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
A theoretical assessment of the toxicokinetic properties of the substance is made using OECD QSAR ToolBox including the hepatic metabolism simulator.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
- Absorption rate - oral (%):
- 50
- Absorption rate - dermal (%):
- 50
- Absorption rate - inhalation (%):
- 100
Additional information
The substance is a non-volatile liquid which shows very low water solubility and has a relatively high logPow (>6 for most components).
Absorption
Consistent with its physicochemical properties, OECD QSAR Toolbox does not predict oral bioavailability for the intact substance (Lipninski’s rule: OASIS). The results of the available oral toxicity studies demonstrate low toxicity; however increased liver weight and clinical chemistry changes seen following repeated dosing do indicate a degree of oral absorption. Dermal absorption is predicted to be low based on the molecular weight, LogP value and water solubility. The extent of inhalation absorption is also likely to be limited. For the purposes of the risk assessment and in the absence of specific data, oral and dermal absorption are assumed (by default) to be equivalent; inhalation absorption is assumed to be twice that of oral absorption (default assumption).
Distribution
The predicted lack of oral bioavailability indicates that consideration of distribution is not relevant; however data from repeated dose toxicity studies indicates distribution at least as far as the liver. There is no evidence for post-hepatic systemic distribution.
Metabolism
OECD QSAR ToolBox (hepatic metabolism simulator) predicts a number of metabolites arising from terminal N-demethylation or hydroxylation of the carbon chain. It is possible that the substance may be metabolically converted into the corresponding fatty acid(s) and subsequently incorporated into normal metabolism.
Excretion
The low water solubility and molecular weight of the substance would indicate that urinary excretion is unlikely; biliary excretion may therefore be more likely and may be reflected in liver weight changes..
Bioaccumulation potential
Components of the substance have a relatively high logPow; however the limited extent of absorption and predicted metabolism indicate that bioaccumulation is unlikely.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
