Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 700-242-3 | CAS number: 62037-80-3
Although positive results were observed in one in vitro clastogenicity study with CHO cells, negative results were observed for in vitro studies in bacterial cells (Salmonella typhimurium and E. coli) and mammalian cells (mouse lymphoma cells). In vivo studies yielded negative results for chromosome aberrations (mouse bone marrow), micronucleus (mouse bone marrow), and UDS (rat liver cells). Therefore, overall, the test substance is considered negative for genotoxicity.
Short description of key information: In Vitro (Mutagenic effects - bacterial): OECD 471; Ames study. Negative. Reliability = 1.. In Vitro (Mutagenic effects – mammalian): OECD 476; Mouse lymphoma study. Negative. Reliability = 1 In Vitro (Clastogenic effects - mammalian): OECD 473; Chromosome aberrations in CHO cells. Positive. Reliability = 1 In Vivo (Clastogenic effects - mammalian): OECD 474; in vivo mouse micronucleus study; Negative at doses up to 1300 mg/kg. Reliability = 1. In Vivo (Clastogenic effects - mammalian): OECD 475; in vivo mouse bone marrow chromosome aberration study; Negative at doses up to 1300 mg/kg. Reliability = 1 In Vivo (Clastogenic effects - mammalian): OECD 486; in vivo rat UDS study; Negative at doses up to 2000 mg/kg. Reliability = 1 Endpoint Conclusion: No adverse effect observed (negative)
The test substance did not produce mutagenicity or clastogenicity when evaluated in laboratory animals. Based on an assessment of the robust genetic toxicity data for this substance, the substance does not need to be classified for mutagenicity according to the EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Close Do not show this message again