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EC number: 701-263-0 | CAS number: -
- Life Cycle description
- Uses advised against
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- Particle size distribution (Granulometry)
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- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
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- Long-term toxicity to aquatic invertebrates
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- Toxicological Summary
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- Acute Toxicity
- Irritation / corrosion
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- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: In accordance with internationally valid GLP principles
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 988
- Report date:
- 1988
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- yes
Test material
- Reference substance name:
- Reaction mass of 2,2'-[methylenebis(4,1-phenyleneoxymethylene)]dioxirane and [2-({2-[4-(oxiran-2-ylmethoxy)benzyl]phenoxy}methyl)oxirane and [2,2'-[methylenebis(2,1-phenyleneoxymethylene)]dioxirane
- EC Number:
- 701-263-0
- Cas Number:
- 9003-36-5
- Molecular formula:
- C6 H6. C3 H5 Cl . C H2 O)x
- IUPAC Name:
- Reaction mass of 2,2'-[methylenebis(4,1-phenyleneoxymethylene)]dioxirane and [2-({2-[4-(oxiran-2-ylmethoxy)benzyl]phenoxy}methyl)oxirane and [2,2'-[methylenebis(2,1-phenyleneoxymethylene)]dioxirane
- Details on test material:
- EPIKOTE 862
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- ANIMALS
Source: Sittingbourne Research Centre Breeding Unit
Age: 3-6 months
Acclimatization: 2 weeks
Housing: singly in stainless steel cages
Food: ad libitum, Standard Rabbit Diet, S.Q.C. and water
Temperature: 16-22 degrees C
Lighting: 12 hour light dark cycle
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- 0.1 mL
- Duration of treatment / exposure:
- The eyes were not washed after treatment
- Observation period (in vivo):
- 7 days
- Number of animals or in vitro replicates:
- 3 male, 3 female
- Details on study design:
- The eye irritancy was assessed using a method based on that described in the OECD Guidelines. 6 rabbits, between 4.2 and 5.1 kg were used. 0.1 mL of undilute test substance was placed into the lower conjunctival sac of one eye on each rabbit and the lids held together for a few seconds to prevent lose of material. The eyes were not washed. An initial pain assessment was made and graded on scale from 1 to 6. The eye irritancy was scored at 1, 4, 24, 48, 72 hours and 7 days after exposure for cornea, iris and conjunctivae using the standard scores.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Other effects:
- No initial pain response
Any other information on results incl. tables
Animal No. and sex |
Initial effect |
|
Time after instillation |
|||||
1 h |
4 h |
24 h |
48 h |
72 h |
7 d |
|||
921 M
923 M
924 M
879 F
878 F
906 F
|
None
None
None
None
None
None
|
Redness Chemosis Opacity Iris
Redness Chemosis Opacity Iris
Redness Chemosis Opacity Iris
Redness Chemosis Opacity Iris
Redness Chemosis Opacity Iris
Redness Chemosis Opacity Iris
|
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0 |
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0 |
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0 |
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0 |
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0 |
0 0 0 0
0 0 0 +0
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0 |
Mean Score
Grade |
1 |
Redness Chemosis Opacity Iris
|
0 0 0 0
|
0 0 0 0
|
0 0 0 0
|
0 0 0 0
|
0 0 0 0
|
0 0 0 0
|
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information
- Conclusions:
- In the rabbit eye irritancy test, 0.1 mL of the test material caused no irritation. On administration of the test material there was no initial pain response.
- Executive summary:
Six adult albino rabbits were used to evaluate eye irritating properties of BPFDGE when instilled in eye. The test substance (0.1 ml undiluted) was instilled in the conjunctiva sac of one eye. Irritation and injury to the cornea, iris, and conjunctiva were scored at 1, 24, 48, 72 hr and 7 days after the initial exposure. Based on the findings from this study, BPFDGE is not an eye irritant.
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