Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 701-263-0 | CAS number: -
Endpoint summary
Administrative data
Description of key information
Minor effects observed at 250 mg/kg/day were judged to have no adverse health effect consequences Therefore the NOAEL for this oral 90-day rat study is 250 mg/kg/day.
Key value for chemical safety assessment
Repeated dose toxicity: via oral route - systemic effects
Endpoint conclusion
- Dose descriptor:
- NOAEL
- 250 mg/kg bw/day
Additional information
The objective of the study was to determine the toxicity of the test article, Bisphenol F DiGlycidyl Ether, following oral (gavage) administration to rats for at least 13 weeks. One high dose female was killed in extremis during Week 12 of the study and considered incidental.
Generally, the test article Bisphenol F DiGlycidyl Ether, was well tolerated when dosed orally by gavage for 13 weeks at 10, 50 and 250 mg/kg/day. Most of the clinical signs were observed in all dose groups, including controls, with the exception of the high stepping gait which was seen in high dose animals only. The significance of this clinical sign in isolation is unclear especially without microscopic findings. The significance of the changes in activity are also unclear since there is a reduction as well as an increase, also there is no relation to dose levels and no microscopic findings. The reduction in body weight gain during the first seven weeks in the high dose males was probably linked with the decreased food consumption. Thus, the effects on high dose male body weights and food consumptions are considered to be minor. The increased liver weight in both sexes was not accompanied by any microscopic changes and was probably caused by increased metabolism in an attempt to metabolize and eliminate the test article. In the absence of any other findings in high dose females, the toxicological importance of the lower adrenal weights than controls is unclear.
Minor effects observed at 250 mg/kg/day were judged to have no adverse health effect consequences Therefore the NOAEL for this oral 90-day rat study is 250 mg/kg/day.
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
