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EC number: 608-454-7 | CAS number: 30290-53-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2018-10-16 - 2018-10-18 (experimental phase)
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- under GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Version / remarks:
- OECD Guideline for Testing of Chemicals No. 202, adopted 13. Apr. 2004:
”Daphnia sp., Acute Immobilisation Test“ - Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.2 (Acute Toxicity for Daphnia)
- Version / remarks:
- Commission Regulation (EC) No. 440/2008, Method C.2. “Daphnia sp. Acute Immo-bilisation Test”, adopted 30. May 2008
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Sodium 3-(2-propyn-1-yloxy)-1-propanesulfonate
- EC Number:
- 608-454-7
- Cas Number:
- 30290-53-0
- Molecular formula:
- C6H9O4NaS
- IUPAC Name:
- Sodium 3-(2-propyn-1-yloxy)-1-propanesulfonate
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- The test item was stored in the test facility in a closed vessel at room temperature (20 ± 5°C).
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations: 0, 100 mg/L
- Sample storage conditions before analysis: no
Test solutions
- Vehicle:
- no
- Remarks:
- test medium was used
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method: A solution containing 100.4 mg/L in dilution water was prepared.
- Evidence of undissolved material (e.g. precipitate, surface film, etc.): none
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: water flea
- Strain/clone: Daphnia magna STRAUS Berlin
- Source: Daphnia magna is bred in the laboratory throughout the year. The animals are kept for the use in toxicity tests. They multiply by parthenogenesis, thus being genetically identical. The husbandry is performed similar to the method described in the OECD guideline.
- Age of parental stock (mean and range, SD):
- Feeding during test: no
- Food type: green algae (Desmodesmus subspicatus)
METHOD FOR PREPARATION AND COLLECTION OF EARLY INSTARS OR OTHER LIFE STAGES:
18 hours 15 minutes before the start of the test, the adult animals were separated from the young. 0.5 hours before test start, the adults were caught with the help of a glass tube, and the newborn daphnia, aged between 18 hours 15 minutes, were sieved from the me-dium and immediately placed into a beaker containing dilution water. After the settling-in period, animals which showed no apparent damage were used for the test.
Switching from M4-medium (husbandry) to Dilution water (test) has been shown not to cause any detrimental effects for test daphnia.
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 48 h
- Post exposure observation period:
- none
Test conditions
- Hardness:
- Resulting hardness in mmol/L: 2.502
Resulting hardness in mg CaCO3/L: 250 - Test temperature:
- 20.5 – 21.8 °C
- pH:
- 7.8
- Dissolved oxygen:
- 8.7 - 8.8 mg/L O2
- Nominal and measured concentrations:
- Nominal: 0 / 100 mg/L
Measured, t=0h: n.d. / 106.5 mg/L
Measured, t=72h: n.d. / 117.8 mg/L - Details on test conditions:
- TEST SYSTEM
- Test vessel: beakers
- Type (delete if not applicable): open
- Material, size, headspace, fill volume: glass beakers, nominal volume 50 mL, tall shape, 20 ± 5 mL fill volume
- Aeration: The dilution water was aerated after preparation.
- Renewal rate of test solution (frequency/flow rate): no
- No. of organisms per vessel: 5
- No. of vessels per concentration (replicates): 5
- No. of vessels per control (replicates): 5
- No. of vessels per vehicle control (replicates): n/a
OTHER TEST CONDITIONS
- Adjustment of pH: no
- Photoperiod: 16/8 hours
- Light intensity: not stated, neon tubes
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) : immobility after 24 and 48 hours, pH and O2 after 0 and 48 hours.
RANGE-FINDING STUDY
The concentrations to be tested are based on the result of a non-GLP pre-test. - Reference substance (positive control):
- yes
- Remarks:
- Potassium dichromate K2Cr2O7 (CAS No. 7778-50-9) was used as positive control in a current reference study.
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- LOEC
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- - Behavioural abnormalities: none
- Mortality of control: none
- Other adverse effects control: none
- Abnormal responses: none
- Any observations (e.g. precipitation) that might cause a difference between measured and nominal values: no
- Effect concentrations exceeding solubility of substance in test medium: none - Results with reference substance (positive control):
- - Results with reference substance valid?
yes
- Relevant effect levels: 24h EC50
- Limit test: no
- Dose-response test: yes
- ECx: The 24h-EC50i value was determined as 1.9 mg/L. The value was within the requested range for the 24h-EC50 between 0.6 - 2.1 mg/L of potassium dichromate K2Cr2O7 as specified in the OECD guideline. Since the fits showed sufficient statistical correspondence of the data with the dose-response-equation, this reference study can be considered valid. - Reported statistics and error estimates:
- Since no toxicity has occurred, no statistical evaluation is performed.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- The study was conducted under GLP according to OECD guideline 202 and EU method C.2 on the registered substance itself. The method is to be considered scientifically reasonable with no deficiencies in documentation or deviations from the guidelines, the validity criteria were met. Positive and negative controls gave the appropriate response. Hence, the results can be considered as reliable to assess the toxicity of POPS-Na towards aquatic invertebrates.
At the beginning and at the end of the test, the content of the test item in the test solutions was determined using HPLC-UV -determination. The concentrations determined at the start of the test were 107 % of the nominal concentration. At the end of the test the determined concentrations were 118 % of the nominal concentration. Therefore, the determination of the biological results was based on the nominal concentration.
The study was performed as a limit test at 100 mg/L. For each test concentration and the blank control, 20 Daphnia were exposed to the test item for 48 hours in a static test system. After 24 and 48 hours, the immobilised Daphnia were counted.
No toxicity could be observed in the treatment. None of the animals was immobilised in the blank control. So the 48h NOEC was so determined to be ≥ 100 mg/L, the EC50 > 100 mg/L. Hence, POPS-Na does not need to be classified as hazardous to the environment according to Regulation 1272/2008 and amendments, neither acute nor chronic. - Executive summary:
The study was conducted under GLP according to OECD guideline 202 and EU method C.2 on the registered substance itself. One valid experiment was performed.
The study was performed as a limit test at 100 mg/L. For each test concentration and the blank control, 20 Daphnia were exposed to the test item for 48 hours in a static test system. After 24 and 48 hours, the immobilised Daphnia were counted.
No toxicity could be observed in the treatment. None of the animals was immobilised in the blank control.
Potassium dichromate K2Cr2O7 (CAS No. 7778-50-9) was used as positive control in a current reference study to assure that the test conditions are reliable.
At the beginning and at the end of the test, the content of the test item in the test solutions was determined using HPLC-UV -determination. The concentrations determined at the start of the test were 107 % of the nominal concentration. At the end of the test the determined concentrations were 118 % of the nominal concentration. Therefore, the determination of the biological results was based on the nominal concentration.
Since no toxicity has occurred, no statistical evaluation is performed.
The following results were determined for the test item Propargyl 3-sulfopropyl ether, sodium salt (POPS-Na) (species: Daphnia magna).
48h-NOEC = ≥ 100 mg/L
48h-LOEC = > 100 mg/L
24h-EC50 = > 100 mg/L
48h-EC50 = > 100 mg/LPOPS-Na does not need to be classified as hazardous to the environment according to Regulation 1272/2008 and amendments, neither acute nor chronic.
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