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EC number: 812-508-7 | CAS number: 1093112-19-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- from 4. Nov. 2016 to 24. Nov. 2016
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 016
- Report date:
- 2016
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Certicate not attached
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- reaction product of alumina and sulfuric acid
- EC Number:
- 812-508-7
- Cas Number:
- 1093112-19-6
- Molecular formula:
- unspecified, UVCB substance
- IUPAC Name:
- reaction product of alumina and sulfuric acid
- Test material form:
- solid: particulate/powder
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- 6 female rats (non-pregnant and nulliparous), 8-12 weeks old, healthy
housed in plastic cages suspended on stainless steel racks, up to 3 animals per cage, average room temperature: 22.1 +/- 0.3°C, relative humidity: 56.2 +/- 2.5%, 12-hours light/12hours dark, bedding: Lignocel S3/4, Lufa - ITL GmbH, Germany
laboratory food ssniff (Spezialdiäten GmbH, Germany), unlimited supply of drinking water (tap water)
Each animal was marked with an ID number on the tail with an ink marker
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- no food over-night before dosing, no food over 3-4 hours after dosing, free access to drinking water
because the test substance seemed to be not toxic, 3 animals were dosed with the limit dose. As no related mortality was observed during 24 hours, a second group of 3 animals was dosed - Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 2 X 3
- Control animals:
- other:
- Details on study design:
- 3 animals were dosed, because no mortality occured during 24 hours, the next 3 animals were dosed too
- Statistics:
- not made
Results and discussion
Effect levels
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat. (total fraction)
- Remarks on result:
- not determinable due to absence of adverse toxic effects
- Mortality:
- none
- Clinical signs:
- during the first 4 hour (very intensive observation) and the 14 day observation period, no clinincal signs were observe
- Body weight:
- stagnation of body weight in 4 from 6 animals
- Gross pathology:
- no macroscopic findings noticed
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The LD50 of the Sulfuric acid, reaction product with alumina is higher than 2000 mg/kg bw
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