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EC number: 458-680-3 | CAS number: 797751-44-1 WASOX-VMAC2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
- Endpoint:
- bioaccumulation in aquatic species, other
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Remarks:
- Internationally accepted method, EPI Suite, EPA (USA)
- Justification for type of information:
- See attached the QMRF and QPRF for the QSAR model.
- Guideline:
- other: REACH Guidance on QSARs R.6
- Principles of method if other than guideline:
- Meylan, W.M., Howard, P.H, Aronson, D., Printup, H. and S. Gouchie. 1997. "Improved Method for Estimating Bioconcentration Factor (BCF) from Octanol-Water Partition Coefficient", SRC TR-97-006 (2nd Update), July 22, 1997; prepared for: Robert S. Boethling, EPA-OPPT, Washington, DC; Contract No. 68-D5-0012; prepared by: ; Syracuse Research Corp., Environmental Science Center, 6225 Running Ridge Road, North Syracuse, NY 13212.
Meylan, W.M., Howard, P.H., Boethling, R.S. et al. 1999. Improved Method for Estimating Bioconcentration / Bioaccumulation Factor from Octanol/Water Partition Coefficient. Environ. Toxicol. Chem. 18(4): 664-672 (1999). - Specific details on test material used for the study:
- SMILES: N(O)=C(C)C
- Key result
- Type:
- BCF
- Value:
- 3.162 L/kg
- Remarks on result:
- other: (Log BCF from regression-based method = 0.500; log Kow used: 0.12)
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- The BCF of acetone oxime was 3.162 L/kg wet-wt (log BCF from regression-based method = 0.500).
- Executive summary:
Using the BCFBAF v3.01 model of EPI Suite v4.11, the BCF of acetone oxime was 3.162 L/kg wet-wt (log BCF from regression-based method = 0.500).
- Endpoint:
- bioaccumulation in aquatic species, other
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Remarks:
- Internationally accepted method, EPI Suite, EPA (USA)
- Justification for type of information:
- See attached the QMRF and QPRF for the QSAR model.
- Guideline:
- other: REACH Guidance on QSARs R.6
- Principles of method if other than guideline:
- Meylan, W.M., Howard, P.H, Aronson, D., Printup, H. and S. Gouchie. 1997. "Improved Method for Estimating Bioconcentration Factor (BCF) from Octanol-Water Partition Coefficient", SRC TR-97-006 (2nd Update), July 22, 1997; prepared for: Robert S. Boethling, EPA-OPPT, Washington, DC; Contract No. 68-D5-0012; prepared by: ; Syracuse Research Corp., Environmental Science Center, 6225 Running Ridge Road, North Syracuse, NY 13212.
Meylan, W.M., Howard, P.H., Boethling, R.S. et al. 1999. Improved Method for Estimating Bioconcentration / Bioaccumulation Factor from Octanol/Water Partition Coefficient. Environ. Toxicol. Chem. 18(4): 664-672 (1999). - Specific details on test material used for the study:
- SMILES: OC
- Key result
- Type:
- BCF
- Value:
- 3.162 L/kg
- Remarks on result:
- other: (Log BCF from regression-based method = 0.500; log Kow used: -0.77)
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- The BCF of methanol was 3.162 L/kg wet-wt (log BCF from regression-based method = 0.500).
- Executive summary:
Using the BCFBAF v3.01 model of EPI Suite v4.11, the BCF of methanol was 3.162 L/kg wet-wt (log BCF from regression-based method = 0.500).
- Endpoint:
- bioaccumulation in aquatic species: fish
- Data waiving:
- study technically not feasible
- Justification for data waiving:
- other:
- Justification for type of information:
- JUSTIFICATION FOR DATA WAIVING
The substance undergoes rapid hydrolysis (half-life < 1h) in aqueous to acetone oxime and the corresponding silanols. Also methanol was identified as a degradation product in the hydrolysis study included in this dossier. At the same time, silanols, i.e. dimethoxyvinylsilanol, methoxyvinylsilanediol and vinylsilanetriol, undergo continuous condensation reaction to produce higher molecular weight siloxanes which are in the molecular weight range large enough to be considered biologically unavailable. Therefore, the potential for bioaccumulation of the test substance is likely due to the acetone oxime and methanol. The estimated log octanol-water partition coefficients (Log Kow) for the degradation products acetone oxime and methanol are 1.20 and -0.63 (EPISuite, KOWWIN v1.68) respectively, which represents a low bioaccumulation potential (log Kow < 3). Furthermore, bioaccumulation of degradation products acetone oxime and methanol has been calculated (EPISuite, BCFBAF v3.01). - Reason / purpose for cross-reference:
- data waiving: supporting information
- Reason / purpose for cross-reference:
- data waiving: supporting information
- Reason / purpose for cross-reference:
- reference to other study
- Reason / purpose for cross-reference:
- reference to other study
Referenceopen allclose all
The BCF of acetone oxime was 3.162 L/kg wet-wt (log BCF from regression-based method = 0.500).
The BCF of methanol was 3.162 L/kg wet-wt (log BCF from regression-based method = 0.500).
Description of key information
Data waiving: The substance undergoes rapid hydrolysis (half-life < 1h) in aqueous to acetone oxime, methanol and the corresponding silanols. At the same time, silanols undergo continuous condensation reaction to produce higher molecular weight siloxanes which are in the molecular weight range large enough to be considered biologically unavailable. Therefore, the potential for bioaccumulation of the test substance is likely due to the acetone oxime and methanol which has been calculated (EPISuite, BCFBAF v3.01).
Key studies: Data from EPI-Suite, EPA (USA) / BCFBAF v3.01 calculation method. The BCF of the degradation products methanol and acetone oxime were calculated to be 3.162 L/kg.
Key value for chemical safety assessment
- BCF (aquatic species):
- 3.162 L/kg ww
Additional information
Data waiving: The substance undergoes rapid hydrolysis (half-life < 1h) in aqueous to acetone oxime and the corresponding silanols. Also methanol was identified as a degradation product in the hydrolysis study included in this dossier. At the same time, silanols, i.e. dimethoxyvinylsilanol, methoxyvinylsilanediol and vinylsilanetriol, undergo continuous condensation reaction to produce higher molecular weight siloxanes which are in the molecular weight range large enough to be considered biologically unavailable. Therefore, the potential for bioaccumulation of the test substance is likely due to the acetone oxime and methanol. The estimated log octanol-water partition coefficients (Log Kow) for the degradation products acetone oxime and methanol are 1.20 and -0.63 (EPISuite, KOWWIN v1.68) respectively, which represents a low bioaccumulation potential (log Kow < 3). Furthermore, bioaccumulation of degradation products acetone oxime and methanol has been calculated (EPISuite, BCFBAF v3.01).
Key studies: Data from EPI-Suite, EPA (USA) / BCFBAF v3.01 calculation method. The BCF of the degradation products methanol and acetone oxime were calculated to be 3.162 L/kg.
According to Annex XIII to REACH, the substance is considered not to fulfil the criterion for bioaccumulation, since the estimated BCF is < 2000.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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