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EC number: 272-702-7
CAS number: 68909-34-2
Zirconium, acetate lactate oxo ammonium
complexes consists of a ammonium [NH4]+ and a zirconium [Zr]4+ ion as
well as an acetic acid [CH3COO]2- and a lactic acid [CH3CH(OH)COO]2-
anion. A complete dissociation of zirconium, acetate lactate oxo
ammonium complexes resulting in ammonium, zirconium, acetate and lactate
ions may be assumed under environmental conditions.
Acetate and lactate under predominating
environmental pH conditions will be present in the ionic forms CH3COO-
and CH3CH(OH)COO- and biodegrade rapidly.
In aquatic and terrestrial environments,
ionic ammonium (NH4+) is in equilibrium with ammonia (NH3), and the
respective speciation is influenced by various parameters, including
temperature, pH, salinity and ionic strength. The main factors, however,
that influence the equilibrium between unionized and ionized ammonia are
pH and temperature (Environment Canada 2010 and references therein).
Raising pH by one unit can cause the unionized ammonia concentration to
increase nearly tenfold whereas a 5 °C temperature increase can cause an
increase of 40-50% (Environment Canada 2010 and references therein). The
ionic strength of the water is also an important influence on the
unionized ammonia concentration. As the ionic strength increases in hard
or marine waters, there is a decrease in the unionized NH3 concentration
(Environment Canada 2010 and references therein). Ammonia (NH3) and
ionic ammonium (NH4+) are referred to as total ammonia nitrogen (TAN).
Based on analysis of thermodynamic stability
of aqueous zirconium species, the concentration of free Zr4+ ions under
environmental conditions is barely detectable. Ionic zirconium (Zr4+) at
relevant pH conditions (pH 7 - 8) of aquatic and terrestrial
environments will rapidly transform to zirconium-oxide and -hydroxide
complexes, precipitate and not be bioavailable to aquatic organisms.
Therefore, zirconium has a very low mobility and bioavailability under
most environmental conditions.
Thus, under environmentally relevant
conditions, acetate, ammonium and lactate are expected to be present in
ionic form and rather mobile whereas zirconium is rather immobile and
complexed as zirconium (hydr)oxides. However, ammonium, acetate and
lactate are expected to be rapidly biodegraded.
Thus, in the assessment of environmental
toxicity and fate of zirconium, acetate lactate oxo ammonium complexes,
read-across to zirconium and ammonium substances as well as acetic and
lactic acid is applied since the individual ions of zirconium, acetate
lactate oxo ammonium complexes determine its environmental fate. Since
the dissociation products behave differently in the environment,
regarding their fate and toxicity, a separate assessment of each
assessment entity is performed. Please refer to the data as submitted
for each individual assessment entity.
In order to evaluate the environmental fate
of zirconium, acetate lactate oxo ammonium complexes, information on the
assessment entities zirconium and ammonium substances as well as acetic
and lactic acid were considered. For a documentation and justification
of that approach, please refer to the separate document attached to
section 13, namely Read Across Assessment Report for zirconium, acetate
lactate oxo ammonium complexes.
Environment Canada (2010). Canadian Council
of Ministers of the Environment. Canadian water quality guidelines for
the protection of aquatic life: Ammonia. In: Canadian environmental
quality guidelines, 1999, Canadian Council of Ministers of the
Aquatic toxicity studies with zirconium,
acetate lactate oxo ammonium complexes are not available, thus aquatic
toxicity is addressed with existing data on the dissociation products.
Zirconium, acetate lactate oxo ammonium complexes dissolves and
dissociates into zirconium, ammonium, acetate and lactate ions upon
dissolution in an aqueous medium.
Acute aquatic toxiciy:
All available acute effect concentrations
and QSAR-based estimates of acetate, ammonium and lactate for toxicity
to algae, daphnia and fish are well above 1 mg/L – the classification
criteria for acute (short-term) hazard.
EC/LC50 values of zirconium are above the
OECD test limit of 100 mg/L for short-term toxicity tests and thus are
also well above the classification criteria for acute (short-term)
Therefore, zirconium, acetate lactate oxo
ammonium complexes does not meet classification criteria as acute hazard
to the aquatic environment under Regulation (EC) No 1272/2008.
Chronic (long-term) toxicity data:
Available long-term effect concentrations
and QSAR-based estimates are well above 1 mg/L– the classification
criteria for long-term hazard of Regulation (EC) No 1272/2008 (CLP
Regulation). Further, all acute effect concentrations and QSAR based
estimates of acetate, ammonium, and lactate are well above 1 mg/L, and
acetate, ammonium and lactate are biodegradable and not bioaccumulative.
Criteria of Category Chronic 1-3 and also 4 (safety net) are not met
The potential of chronic toxicity of
zirconium is expected to be low based on the following:
- no acute toxicity to algae, crustacea and
fish up to the OECD test limit of 100 mg/L for short-term toxicity tests
for zirconium cations
- Zirconium is poorly soluble and
precipitates under most environmental conditions rendering zirconium
- available chronic EC for zirconium, i.e.
the 72h- NOErL (growth rate of algae) = 32 mg/L, is above the OECD test
limit of 10 mg/L for chronic toxicity tests
- Criteria of Category Chronic 1-3 and also
4 (safety net) are not met
Therefore, zirconium, acetate lactate oxo
ammonium complexes does not meet classification criteria as long-term
hazard to the aquatic environment under Regulation (EC) No 1272/2008.
In sum, based on read-across of toxicity
data available for the respective assessment entities (i.e. acetate,
ammonium, lactate and zirconium), zirconium, acetate lactate oxo
ammonium complexes does not meet acute or long-term aquatic hazard
criteria of Regulation (EC) No 1272/2008 and subsequent adaptations.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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