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EC number: 947-766-0 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
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- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
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- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
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- Specific investigations
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- Additional toxicological data

Solubility in organic solvents / fat solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- solubility in organic solvents / fat solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From December 11, 2017 to December 12, 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- other: CIPAC MT 181: “Solubility in organic solvents”, CIPAC Handbook H, 1998
- Deviations:
- no
- Principles of method if other than guideline:
- This study is performed in order to determine the miscibility of test substance with solvent n-octanol according to CIPAC MT 181. The test substance is mixed with different amounts of n-octanol. From the total volume which is required for complete dissolution of a certain mass of the test substance, examined after at least 30 minutes visually, the solubility in n-octanol is determined.
- GLP compliance:
- yes (incl. QA statement)
- Key result
- Medium:
- n-octanol
- Solubility:
- ca. 80 - ca. 100 g/L
- Temp.:
- 25 °C
- Test substance stable:
- not determined
- Details on results:
- The test showed good repeatability. Solubility in n-octanol is 80 – 100 g/L.
- Conclusions:
- Under the study conditions, n-octanol solubility of the test substance was determined to be in range of 80-100 g/L.
- Executive summary:
A study was conducted to determine the n-octanol solubility of the test substance, Quaternary ammonium compounds, N,N,N'-tris(hydroxyethyl)-N,N'-dimethyl-N'-tallow alkyltrimethylenedi-, bis(Me sulfates) (salts), according to the CIPACMT 181 Guideline. In preliminary study in a 10 mL centrifuge vial, 0.1 g of the test substance was weighed. n-octanol was added to final volumes 0.5 mL, 1 mL and 2 mL. After each addition of an amount of solvent, the mixture was vigorously shaken and stored with intermittent shaking at 25.0°C for 10 minutes. In n-octanol dissolution of 50 – 100 g/L of the test substance was observed. In main test in a 10 mL graduated centrifuge vial, 0.2 g of the test substance was weighed n-octanol was added to final volumes of 2 and 2.5 mL. The mixture was vigorously shaken and stored at 25.0 – 25.1°C for 30 minutes with intermittent shaking. In n-octanol dissolution of 80 – 100 g/L of the test substance was observed. Under the study conditions, n-octanol solubility of the test substance was determined to be in range of 80-100 g/L (Brinkmann, 2018).
Reference
Pre-test n-octanol
Weight test substance [g] |
0.1002 |
||
Added Volume [mL] |
0.5 |
1.0 |
2.0 |
Approx. Solubility [g/L] |
> 200 |
100-200 |
50-100 |
Dissolution |
no |
no |
yes |
In n-octanol dissolution of 50 – 100 g/L of the test substance was observed.
Main-test, 1 determination
Weight test item [g] | 0.2009 | |
Added Volume [mL] | 2 | 2.5 |
Approx. Solubility [g/L] | > 100 | 80-100 |
Dissolution | no | yes |
Temperature [°C]* | 25 | 25.1 |
*Temperature was determined with a glass thermometer.
Main-test, 2 determination
Weight test substance [g] | 0.2001 | |
Added Volume [mL] | 2 | 2.5 |
Approx. Solubility [g/L] | > 100 | 80-100 |
Dissolution | no | yes |
Temperature [°C]* | 25 | 25.1 |
*Temperature was determined witha glass thermometer.
Description of key information
The n-octanol solubility was determined according to CIPACMT Guideline 181 (Brinkmann, 2018).
Key value for chemical safety assessment
- Solubility in organic solvents at 20°C:
- 100 g/L
Additional information
n-octanol solubility of the test substance was determined to be in range of 80-100 g/L at 25.0 – 25.1°C.
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