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Diss Factsheets
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EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 2S,3S,4S,5R,6R)-6-[(2R,3R,4R,5R,6R)-3-acetamido-2,5-dihydroxy-6-sulfooxyoxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid
- Molecular formula:
- (C14H19Na2NO14S)n
- IUPAC Name:
- 2S,3S,4S,5R,6R)-6-[(2R,3R,4R,5R,6R)-3-acetamido-2,5-dihydroxy-6-sulfooxyoxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- Source: Szent István University, Department of Aquaculture 2100 Gödöllő, Páter Károly u. 1. – Hungary
Test conditions
- Hardness:
- The reconstituted water (ISO medium) had a total hardness of 246 mg/L (as CaCO3).
- Test temperature:
- The water temperature was measured at the start of the test and 24-hour intervals thereafter in each test vessel. The test temperature was in the range of 20.4 – 20.9°C measured in the test vessels.
The additionally measured temperature in the climate chamber was between 19.9 and 21.1°C. - pH:
- The pH of the test solution was not adjusted and not varied by more than 1.5 units in any one test. The pH was measured at the start and at the end of each renewal period in each test vessel and was in the range of 7.46 – 7.86.
- Dissolved oxygen:
- The dissolved oxygen concentration was measured in each test vessel at the start and at the end of each renewal period and was in the range of 7.6– 8.8 mg/L
- Nominal and measured concentrations:
- Nominal concentrations
[mg/L nominal loading rates WAFs]
0.1 1 10 100 - Details on test conditions:
- Light: The test was carried out in 16-hour light and 8-hour dark cycle.
- Reference substance (positive control):
- yes
Results and discussion
Effect concentrationsopen allclose all
- Key result
- Duration:
- 48 h
- Dose descriptor:
- NOELR
- Effect conc.:
- 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Key result
- Duration:
- 48 h
- Dose descriptor:
- LOELR
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Key result
- Duration:
- 48 h
- Dose descriptor:
- other: ELR50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- Under the conditions of this Daphnia magna acute immobilisation study the calculated and observed endpoints for the effect of Test Item were the followings:
The 24h, 48h, ELR50 value: > 100 mg/L nominal loading rate WAF
The 48h ELR100 value: > 100 mg/L nominal loading rate WAF
The 48h NOELR : 100 mg/L nominal loading rate WAF
The 48h LOELR : > 100 mg/L nominal loading rate WAF
Based on the results of this study, the Test Item had no toxic effect at saturation on Daphnia; the ELR50 results and the LOELR are higher than the solubility level of the Test Item in the test medium.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Executive summary:
Acute toxicity of Test Item was assessed with Acute Immobilisation Test on Daphnia magna, over an exposure period of 48 hours in a semi-static system.
Because no toxic effect was observed at the solubility level of the Test Item in the preliminary test, only this test concentration 100 mg/L Test Item nominal loading rate (WAF) at the solubility level of the Test Item in the test medium and one control group were tested in a limit test in the definitive study.
Based on the agreement with the Sponsor and due to the fact that the Test Item is an UVCB the analytical measurement was performed by TOC analysis. Only the sum of the carbon content of the Test Item could be measured this way.
Twenty animals, divided into 4 groups (glass beaker) of 5 animals each were used at the test and for the control group. All validity criteria were met during this study.
Under the conditions of this Daphnia magna acute immobilisation study the calculated and observed endpoints for the effect of Test Item were the followings:
The 24h, 48h, ELR50value: >100 mg/L nominal loading rate WAF
The 48h ELR100[1]value: >100 mg/L nominal loading rate WAF
The 48h NOELR[2]: 100 mg/L nominal loading rate WAF
The 48h LOELR[3]: >100 mg/L nominal loading rate WAF
Based on the results of this study, the Test Item had no toxic effect at saturation on Daphnia; the ELR50results and the LOELR are higher than the solubility level of the Test Item in the test medium.
[1] Effective Loading rate.
[2] No-Observed Effect Loading rate.
[3] Lowest Observed Effect Loading rate.
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