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Long-term toxicity to aquatic invertebrates

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Reference
Endpoint:
long-term toxicity to aquatic invertebrates
Type of information:
(Q)SAR
Adequacy of study:
key study
Study period:
May 2018
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: This summary has a reliability of 2 because the results are estimated using a computer model that is appropriate for use with this hydrocarbon substance
Justification for type of information:
The aquatic toxicity was estimated by a QSAR, the Petrotox computer model (v 3.06). This model combines a partitioning model used to calculate the aqueous concentration of hydrocarbon components with the Target Lipid Model used to calculate acute and chronic toxicity of non-polar narcotic chemicals. Petrotox computes toxicity based on the summation of the aqueous-phase concentrations of hydrocarbon block(s) that represent a hydrocarbon substance and membrane-water partition coefficients (KMW) that describe the partitioning of the hydrocarbons between the water and organism.
Qualifier:
no guideline followed
Principles of method if other than guideline:
The aquatic toxicity was estimated by a QSAR, the Petrotox computer model (v 3.06). This model combines a partitioning model used to calculate the aqueous concentration of hydrocarbon components with the Target Lipid Model used to calculate acute and chronic toxicity of non-polar narcotic chemicals. Petrotox computes toxicity based on the summation of the aqueous-phase concentrations of hydrocarbon block(s) that represent a hydrocarbon substance and membrane-water partition coefficients (KMW) that describe the partitioning of the hydrocarbons between the water and organism.
GLP compliance:
no
Remarks:
The data were calculated by a computer model.
Specific details on test material used for the study:
No data
Analytical monitoring:
no
Details on sampling:
No data
Vehicle:
no
Details on test solutions:
No data
Test organisms (species):
Daphnia magna
Details on test organisms:
No data
Test type:
other: QSAR modeled data
Water media type:
freshwater
Limit test:
no
Total exposure duration:
21 d
Hardness:
No data
Test temperature:
No data
pH:
No data
Dissolved oxygen:
No data
Salinity:
No data
Nominal and measured concentrations:
No data
Details on test conditions:
No data
Reference substance (positive control):
not required
Key result
Duration:
21 d
Dose descriptor:
NOELR
Effect conc.:
1.2 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
reproduction
Details on results:
No data
Results with reference substance (positive control):
No data
Reported statistics and error estimates:
No data

The composition used to run the Petrotox model is below, derived from GCxGC data for the substance;

 Carbon Number  MoAr  NMAr  DiAr
 9  73.599  
 10  23.035  1.129  2.237
Validity criteria fulfilled:
yes
Conclusions:
The estimated freshwater invertebrate 21-day NOELR (Lowest Observed Effect Loading Rate) value is 1.2 mg/l based on reproduction.
Executive summary:

The aquatic toxicity was estimated using the Petrotox computer model, which combines a partitioning model used to calculate the aqueous concentration of hydrocarbon components as a function of substance loading with the Target Lipid Model used to calculate acute and chronic toxicity of non-polar narcotic chemicals. Petrotox computes toxicity based on the summation of the aqueous-phase concentrations of hydrocarbon block(s) that represent a hydrocarbon substance and membrane-water partitioning coefficients (KMW) that describe the partitioning of the hydrocarbons between the water and organism. The estimated freshwater invertebrate 21-day NOELR (Lowest Observed Effect Loading Rate) value is 1.2 mg/L based on reproduction.

Description of key information

Petrotox has been run on the substance Hydrocarbons, C9-C10, aromatics, >1% Naphthalene and is presented below.

 

The estimated freshwater invertebrate 21-day NOELR (No Observed Effect Loading Rate) value for Hydrocarbons, C9-C10, aromatics, >1% naphthalene is 1.2 mg/L, based on reproduction.

Key value for chemical safety assessment

Additional information

The aquatic toxicity was estimated using the Petrotox computer model, which combines a partitioning model used to calculate the aqueous concentration of hydrocarbon components as a function of substance loading with the Target Lipid Model used to calculate acute and chronic toxicity of non-polar narcotic chemicals. Petrotox computes toxicity based on the summation of the aqueous-phase concentrations of hydrocarbon block(s) that represent a hydrocarbon substance and membrane-water partitioning coefficients (KMW) that describe the partitioning of the hydrocarbons between the water and organism.

 

The estimated freshwater invertebrate 21-day NOELR (No Observed Effect Loading Rate) value for Hydrocarbons, C9-C10, aromatics, >1% naphthalene is 1.2 mg/L, based on reproduction.