Registration Dossier
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EC number: 701-129-1 | CAS number: -
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
EC10 (21d) = 1.76 mg/L (active ingredient, mortality) for Daphnia magna (OECD 202 partII, read across)
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 1.76 mg/L
Additional information
No study investigating the long-term toxicity of D-Glucopyranose, oligomeric, C10-16-alkyl glycosides, carboxymethyl ethers, sodium salts (CAS 383178-66-3) to aquatic invertebrates is available.Thus, an analogue substance (D-Glucopyranose, oligomeric, C10-16-alkyl glycosides, CAS 110615-47-9) is used in a read across approach to assess the algal toxicity of the target substance to freshwater algae. The read across is based on structural similarity between the target substance and the supporting substance. The target substance is a derivative of the supporting substance, where a carboxymethy group is added to a -OH function. All other structural elements (alkyl side chain, glycoside moiety) are identical. The additional carboxymethyl group renders the substance more hydrophilic, which usually decreases aquatic toxicity. This is confirmed by the acute ecotox data of the target substance (TS) and the supporting substance (SS): Fish: 7.1 mg/L (TS) vs 3.0 mg/L (SS); Invertebrates: 172 mg/L (TS) vs 7.0 mg/L (SS). Therefore, read across from D-Glucopyranose, oligomeric, C10-16-alkyl glycosides to D-Glucopyranose, oligomeric, C10-16-alkyl glycosides, carboxymethyl ethers, sodium salt is fully justified as this is considered to be a worst case approach.
The long-term effects of the read across substance towards aquatic invertebrates were evaluated in a 21 d test with Daphnia magna performed according to the OECD guideline 202 part II (Stelter 1995). The test design was semi-static with a daily renewal of the test substance und growth medium. The test exhibited an EC10 value (21 d) of 1.76 mg a.i./L for the endpoint mortality and a NOEC (21 d) of 2 mg a.i./L for the endpoint reproduction, respectively.
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