Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Workers - Hazard via inhalation route

Systemic effects

Long term exposure
Hazard assessment conclusion:
DNEL (Derived No Effect Level)
Value:
4 450 000 µg/m³
Most sensitive endpoint:
repeated dose toxicity
Route of original study:
By inhalation
DNEL related information
DNEL derivation method:
ECHA REACH Guidance
Overall assessment factor (AF):
30
AF for dose response relationship:
1
Justification:
standard assessment factor
AF for differences in duration of exposure:
6
Justification:
standard assessment factor
AF for interspecies differences (allometric scaling):
1
Justification:
standard assessment factor
AF for other interspecies differences:
1
Justification:
standard assessment factor
AF for intraspecies differences:
5
Justification:
standard assessment factor
AF for the quality of the whole database:
1
Justification:
standard assessment factor
AF for remaining uncertainties:
1
Justification:
not present
Acute/short term exposure
Hazard assessment conclusion:
DNEL (Derived No Effect Level)
Value:
225 mg/m³
Most sensitive endpoint:
acute toxicity
Route of original study:
By inhalation
DNEL related information
DNEL derivation method:
ECHA REACH Guidance
Overall assessment factor (AF):
20
AF for dose response relationship:
1
Justification:
standard default
AF for interspecies differences (allometric scaling):
4
Justification:
standard default
AF for other interspecies differences:
1
Justification:
standard default
AF for intraspecies differences:
5
Justification:
standard default
AF for the quality of the whole database:
1
Justification:
standard default
AF for remaining uncertainties:
1
Justification:
standard default

Local effects

Long term exposure
Hazard assessment conclusion:
DNEL (Derived No Effect Level)
Value:
0.268 mg/m³
Most sensitive endpoint:
acute toxicity
DNEL related information
DNEL derivation method:
ECHA REACH Guidance
Overall assessment factor (AF):
5
AF for dose response relationship:
1
Justification:
standard default
AF for differences in duration of exposure:
1
Justification:
standard default
AF for interspecies differences (allometric scaling):
1
Justification:
standard default
AF for other interspecies differences:
5
Justification:
standard default
AF for intraspecies differences:
1
Justification:
standard default
AF for the quality of the whole database:
1
Justification:
standard default
AF for remaining uncertainties:
1
Justification:
standard default
Acute/short term exposure
Hazard assessment conclusion:
DNEL (Derived No Effect Level)
Value:
0.9 mg/m³
Most sensitive endpoint:
repeated dose toxicity
DNEL related information
DNEL derivation method:
ECHA REACH Guidance
Overall assessment factor (AF):
5
AF for dose response relationship:
1
Justification:
standard default
AF for interspecies differences (allometric scaling):
1
Justification:
standard default
AF for other interspecies differences:
1
Justification:
standard default
AF for intraspecies differences:
5
Justification:
standard default
AF for the quality of the whole database:
1
Justification:
standard default
AF for remaining uncertainties:
1
Justification:
standard default

Workers - Hazard via dermal route

Systemic effects

Long term exposure
Hazard assessment conclusion:
no hazard identified
Acute/short term exposure
Hazard assessment conclusion:
DNEL (Derived No Effect Level)
Value:
100 mg/kg bw/day
Most sensitive endpoint:
acute toxicity
Route of original study:
Dermal
DNEL related information
DNEL derivation method:
ECHA REACH Guidance
Overall assessment factor (AF):
20
AF for dose response relationship:
1
Justification:
standard default
AF for interspecies differences (allometric scaling):
4
Justification:
standard default
AF for other interspecies differences:
1
Justification:
standard default
AF for intraspecies differences:
5
Justification:
standard default
AF for the quality of the whole database:
1
Justification:
standard default
AF for remaining uncertainties:
1
Justification:
standard default

Local effects

Long term exposure
Hazard assessment conclusion:
no hazard identified
Acute/short term exposure
Hazard assessment conclusion:
DNEL (Derived No Effect Level)
Value:
400 mg/cm²
Most sensitive endpoint:
acute toxicity
DNEL related information
Overall assessment factor (AF):
5
AF for dose response relationship:
1
Justification:
standard default
AF for interspecies differences (allometric scaling):
1
Justification:
standard default
AF for other interspecies differences:
1
Justification:
standard default
AF for intraspecies differences:
5
Justification:
standard default
AF for the quality of the whole database:
1
Justification:
standard default
AF for remaining uncertainties:
1
Justification:
standard default

Workers - Hazard for the eyes

Local effects

Hazard assessment conclusion:
no hazard identified

Additional information - workers

General Population - Hazard via inhalation route

Systemic effects

Long term exposure
Hazard assessment conclusion:
DNEL (Derived No Effect Level)
Value:
0.2 mg/m³
Most sensitive endpoint:
repeated dose toxicity
DNEL related information
Overall assessment factor (AF):
10
AF for dose response relationship:
1
Justification:
standard default
AF for differences in duration of exposure:
1
Justification:
standard default
AF for interspecies differences (allometric scaling):
1
Justification:
standard default
AF for other interspecies differences:
1
Justification:
standard default
AF for intraspecies differences:
10
Justification:
standard default
AF for the quality of the whole database:
1
Justification:
standard default
AF for remaining uncertainties:
1
Justification:
standard default
Acute/short term exposure
Hazard assessment conclusion:
DNEL (Derived No Effect Level)
Value:
0.112 mg/m³
Most sensitive endpoint:
acute toxicity
DNEL related information
DNEL derivation method:
ECHA REACH Guidance
Overall assessment factor (AF):
40
AF for dose response relationship:
1
Justification:
standard default
AF for interspecies differences (allometric scaling):
4
Justification:
standard default
AF for other interspecies differences:
1
Justification:
standard default
AF for intraspecies differences:
10
Justification:
standard default
AF for the quality of the whole database:
1
Justification:
standard default
AF for remaining uncertainties:
1
Justification:
standard default

Local effects

Long term exposure
Hazard assessment conclusion:
DNEL (Derived No Effect Level)
Value:
0.2 mg/m³
Most sensitive endpoint:
repeated dose toxicity
DNEL related information
Overall assessment factor (AF):
10
AF for dose response relationship:
1
Justification:
standard default
AF for differences in duration of exposure:
1
Justification:
standard default
AF for interspecies differences (allometric scaling):
1
Justification:
standard default
AF for other interspecies differences:
1
Justification:
standard default
AF for intraspecies differences:
10
Justification:
standard default
AF for the quality of the whole database:
1
Justification:
standard default
AF for remaining uncertainties:
1
Justification:
standard default
Acute/short term exposure
Hazard assessment conclusion:
DNEL (Derived No Effect Level)
Value:
0.45 mg/m³
DNEL related information
Overall assessment factor (AF):
10
AF for dose response relationship:
1
Justification:
standard default
AF for interspecies differences (allometric scaling):
1
Justification:
standard default
AF for other interspecies differences:
1
Justification:
standard default
AF for intraspecies differences:
10
Justification:
standard default
AF for the quality of the whole database:
1
Justification:
standard default
AF for remaining uncertainties:
1
Justification:
standard default

General Population - Hazard via dermal route

Systemic effects

Long term exposure
Hazard assessment conclusion:
no hazard identified
Acute/short term exposure
Hazard assessment conclusion:
DNEL (Derived No Effect Level)
Value:
50 mg/kg bw/day
Most sensitive endpoint:
acute toxicity
Route of original study:
Dermal
DNEL related information
Overall assessment factor (AF):
40
AF for dose response relationship:
1
Justification:
standard default
AF for interspecies differences (allometric scaling):
4
Justification:
standard default
AF for other interspecies differences:
1
Justification:
standard default
AF for intraspecies differences:
10
Justification:
standard default
AF for the quality of the whole database:
1
Justification:
standard default
AF for remaining uncertainties:
1
Justification:
standard default

Local effects

Long term exposure
Hazard assessment conclusion:
no hazard identified
Acute/short term exposure
Hazard assessment conclusion:
DNEL (Derived No Effect Level)
Value:
200 mg/cm²
Most sensitive endpoint:
acute toxicity
DNEL related information
Overall assessment factor (AF):
10
AF for dose response relationship:
1
Justification:
standard default
AF for interspecies differences (allometric scaling):
1
Justification:
standard default
AF for other interspecies differences:
1
Justification:
standard default
AF for intraspecies differences:
10
Justification:
standard default
AF for the quality of the whole database:
1
Justification:
standard default
AF for remaining uncertainties:
1
Justification:
standard default

General Population - Hazard via oral route

Systemic effects

Long term exposure
Hazard assessment conclusion:
no hazard identified
Acute/short term exposure
Hazard assessment conclusion:
DNEL (Derived No Effect Level)
Value:
37.5 mg/kg bw/day
Most sensitive endpoint:
acute toxicity
Route of original study:
Oral
DNEL related information
Overall assessment factor (AF):
40
AF for dose response relationship:
1
Justification:
standard default
AF for interspecies differences (allometric scaling):
4
Justification:
standard default
AF for other interspecies differences:
1
Justification:
standard default
AF for intraspecies differences:
10
Justification:
standard default
AF for the quality of the whole database:
1
Justification:
standard default
AF for remaining uncertainties:
1
Justification:
standard default

General Population - Hazard for the eyes

Local effects

Hazard assessment conclusion:
no hazard identified

Additional information - General Population