Registration Dossier
Registration Dossier
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EC number: 618-780-1 | CAS number: 916809-14-8
Toxicity to terrestrial plants
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
There is no literature available on the effects of NPPT on terrestrial organisms. However, two publications by Krogmeier et al. (1988) and Watson and Miller (1996) could be attained which are dealing with the phytotoxicity of the analog substance NBPT.
NBPT and NPPT have similar modes of action, differ structurally only in one methylene group and are subject to similar degradation and metabolism processes.
Krogmeier et al. investigated the occurence of leaf-tip necrosis in Triticum aestivum and Sorghum bicolor after the application of urea fertilizer in combination with NBPT. Results show that leaf-tip necrosis in Triticum aestivum increased by nearly 25 % after the application of 10 mg NBPT / kg soil (EC25 = 10 mg/kg). However, the authors concluded that this phytotoxicity was the result of accumulation of toxic amounts of urea in the plants through inhibition of the urease activity by NBPT. Hence, the necrosis appears to be rather an indirect effect of NBPT. This finding is supported by Watson and Miller who conducted short-term tests with urea amended with NBPT on perennial ryegrass. They concluded in their study - like Krogmeier et al. - that the phytotoxicity is induced through uptake of urea as an indirect effect of the addition of NBPT. Under normal conditions, urea is rapidly hydrolysed to NH4 +-N in soil so plants would rarely take up urea as the intact molecule. If urea hydrolysis however is delayed through urease inhibitors, urea can be taken up by plants and induce necrosis. However, the authors also stated that the observed effects are transient and unlikely to have any long term adverse impact on plant growth.
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