Registration Dossier
Registration Dossier
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EC number: 201-663-0 | CAS number: 86-30-6
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Metabolic dinitrosation of diphenylnitrosamine: a possible bioactivation pathway
- Author:
- Appel KE, Görsdorf S, Scheper T, Ruf HH, Rühl CS, Hildebrandt AG.
- Year:
- 1 987
- Bibliographic source:
- J.Cancer Res.Clin.Oncol. 113: 131:136
Materials and methods
- Objective of study:
- metabolism
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The metabolism of nitrosodiphenylamine was investigated in phenobarbital-induced mouse liver microsomes and some of the metabolites were also tested.
- GLP compliance:
- no
Test material
- Reference substance name:
- Nitrosodiphenylamine
- EC Number:
- 201-663-0
- EC Name:
- Nitrosodiphenylamine
- Cas Number:
- 86-30-6
- Molecular formula:
- C12H10N2O
- IUPAC Name:
- N-nitroso-N-phenylaniline
Constituent 1
- Radiolabelling:
- no
Test animals
- Species:
- other: mice liver cells
Results and discussion
Metabolite characterisation studies
- Metabolites identified:
- yes
- Details on metabolites:
- Besides the parent compound, three metabolites were found, one of which was diphenylamine. The two other metabolites were identified as 4-hydroxydiphenylamine and its oxidized product, the corresponding quinoneimine.
Applicant's summary and conclusion
- Executive summary:
The metabolism of nitrosodiphenylamine was investigated in phenobarbital-induced mouse liver microsomes and some of the metabolites were also tested.
One metabolite was identified as diphenylamine whereas the others were identified as a ring-hydroxylated derivative of diphenylamine and its corresponding quinoneimine.
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