2-Butyne-1,4-diol, reaction products with 1,2-oxathiolane 2,2-dioxide and sodium hydroxide

Eye irritation

Administrative data

Endpoint:

eye irritation: in vitro / ex vivo

Data waiving:

study scientifically not necessary / other information available

Justification for data waiving:

the study does not need to be conducted because the substance is a strong acid (pH <= 2.0) or base (pH => 11.5) and the available information indicates that it should be classified as serious eye damage (Category 1)

Cross-reference

Cross-reference 1

Reason / purpose for cross-reference:

data waiving: supporting information

Reference

Name:

2-Butyne-1,4-diol, reaction products with 1,2-oxathiolane 2,2-dioxide and sodium hydroxide

Implementation:

EU

Type of classification:

self-classification

Related composition:

2-Butyne-1,4-diol, reaction products with 1,2-oxathiolane 2,2-dioxide and sodium hydroxide

Reason for no classification:

data conclusive but not sufficient for classification

Reason for no classification:

data conclusive but not sufficient for classification

Reason for no classification:

data lacking

Reason for no classification:

hazard class not assessed

Reason for no classification:

data conclusive but not sufficient for classification

Reason for no classification:

data conclusive but not sufficient for classification

Reason for no classification:

data conclusive but not sufficient for classification

Reason for no classification:

data conclusive but not sufficient for classification

Reason for no classification:

data conclusive but not sufficient for classification

Reason for no classification:

data conclusive but not sufficient for classification

Reason for no classification:

data conclusive but not sufficient for classification

Reason for no classification:

data conclusive but not sufficient for classification

Reason for no classification:

data conclusive but not sufficient for classification

Reason for no classification:

data conclusive but not sufficient for classification

Reason for no classification:

data conclusive but not sufficient for classification

Reason for no classification:

data conclusive but not sufficient for classification

Reason for no classification:

data lacking

Reason for no classification:

data lacking

Reason for no classification:

data lacking

Reason for no classification:

data lacking

Reason for no classification:

data lacking

Hazard category:

Skin Corr. 1C

Hazard statement:

H314: Causes severe skin burns and eye damage.

Hazard category:

Eye Damage 1

Hazard statement:

H318: Causes serious eye damage.

Reason for no classification:

data lacking

Reason for no classification:

data lacking

Reason for no classification:

data lacking

Reason for no classification:

data lacking

Reason for no classification:

data lacking

Reason for no classification:

data conclusive but not sufficient for classification

Reason for no classification:

data lacking

Reason for no classification:

data lacking

Reason for no classification:

data lacking

Reason for no classification:

data conclusive but not sufficient for classification

Reason for no classification:

data conclusive but not sufficient for classification

Reason for no classification:

data lacking

Signal word:

Danger

Code:

GHS05: corrosion

Hazard statement:

H314: Causes severe skin burns and eye damage.

Precautionary statement:

P260: Do not breathe dust/fume/gas/mist/vapours/spray.

Precautionary statement:

P280: Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...

Precautionary statement:

P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Precautionary statement:

P303+P361+P353: IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water [or shower].

Precautionary statement:

P304+P340: IF INHALED: Remove person to fresh air and keep comfortable for breathing.

Precautionary statement:

P310: Immediately call a POISON CENTER/doctor/…

Precautionary statement:

P405: Store locked up.

Precautionary statement:

P501: Dispose of contents/container to ...

Cross-reference 2

Reason / purpose for cross-reference:

data waiving: supporting information

Reference

Endpoint:

pH

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Remarks:

Information was taken from the company's in-house analytical summary. As it is necessary to determine the product's specification correctly, it is concluded that the results are sufficiently reliable for assessment.

Qualifier:

no guideline followed

Principles of method if other than guideline:

pH was determined

GLP compliance:

no

pH value:

13.2

Concentration:

43.6 vol%

pH value:

12.6

Concentration:

43.6 vol%

Conclusions:

A 43.6% solution of 2-Butyne-1,4-diol, reaction products with 1,2-oxathiolane 2,2-dioxide and sodium hydroxide in water has a pH value of 13.2 and 12.6 (two independent determinations). Information is expected to have been gathered scientifically reasonable, and it can be concluded that the solution exhibits corrosive effects.

Executive summary:

The pH of a 43.6% solution of 2-Butyne-1,4-diol, reaction products with 1,2-oxathiolane 2,2-dioxide and sodium hydroxide in water was determined as 13.6 resp. 12.6 in two independent experiments.

Cross-reference 3

Reason / purpose for cross-reference:

data waiving: supporting information

Reference

Endpoint:

pH

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Qualifier:

no guideline followed

Principles of method if other than guideline:

pH was measured with pH meter

GLP compliance:

no

Key result

pH value:

12.2

Concentration:

43.6 vol%

Conclusions:

A 43.6% solution of 2-Butyne-1,4-diol, reaction products with 1,2-oxathiolane 2,2-dioxide and sodium hydroxide in water has a pH value of 12.2. Information was gathered scientifically reasonable, and it can be concluded that the solution exhibits corrosive effects.

Executive summary:

The pH of a 43.6% solution of 2-Butyne-1,4-diol, reaction products with 1,2-oxathiolane 2,2-dioxide and sodium hydroxide in water was determined as 12.2 using a pH meter.