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Toxicity to microorganisms

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Description of key information

Key value for chemical safety assessment

EC10 or NOEC for microorganisms:
30 mg/L

Additional information

Since no studies on the toxicity to aquatic microorganisms are available a ready biodegradability study is used to derive a NOEC for the toxicity to aquatic microorganisms. If a compound degrades well in a ready biodegradability test, or does not inhibit the degradation of a positive control at a certain concentration, this concentration can be used as a NOEC value. This approach is in accordance with the Guidance on information requirements and chemical safety assessment (Chapter R.7b: Endpoint specific guidance, ECHA 2017).

A substance can be assumed to be not inhibitory to aquatic microorganisms, if in the toxicity control of a ready biodegradation test, more than 25% degradation based on [oxygen demand (BOD/ThOD)] occurred within 14 days (OECD guideline 301). For fatty acids C18-C22 (even numbered), tetraesters with pentaerythritol a biodegradation test according to OECD guideline 301F is available (Katagiri, 2018). The test includes a toxicity control, which contains 9 mg of [fatty acids C18-C22 (even numbered), tetraesters with pentaerythritol] and 30 mg/L of the reference material [e.g. sodium benzoate]. The toxicity control attained 58 % degradation after 14 days of incubation. Hence, the substance is not toxic to aquatic microorganisms in the toxicity control and the test item concentration of 30 mg/L can be used as NOEC.