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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Toxicity to microorganisms

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Administrative data

Link to relevant study record(s)

Description of key information

Key value for chemical safety assessment

EC10 or NOEC for microorganisms:
30 mg/L

Additional information

Since no studies on the toxicity to aquatic microorganisms are available a ready biodegradability study is used to derive a NOEC for the toxicity to aquatic microorganisms. If a compound degrades well in a ready biodegradability test, or does not inhibit the degradation of a positive control at a certain concentration, this concentration can be used as a NOEC value. This approach is in accordance with the Guidance on information requirements and chemical safety assessment (Chapter R.7b: Endpoint specific guidance, ECHA 2017).

A substance can be assumed to be not inhibitory to aquatic microorganisms, if in the toxicity control of a ready biodegradation test, more than 25% degradation based on [oxygen demand (BOD/ThOD)] occurred within 14 days (OECD guideline 301). For fatty acids C18-C22 (even numbered), tetraesters with pentaerythritol a biodegradation test according to OECD guideline 301F is available (Katagiri, 2018). The test includes a toxicity control, which contains 9 mg of [fatty acids C18-C22 (even numbered), tetraesters with pentaerythritol] and 30 mg/L of the reference material [e.g. sodium benzoate]. The toxicity control attained 58 % degradation after 14 days of incubation. Hence, the substance is not toxic to aquatic microorganisms in the toxicity control and the test item concentration of 30 mg/L can be used as NOEC.