Registration Dossier
Registration Dossier
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EC number: 947-899-4 | CAS number: -
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
- EC10 or NOEC for microorganisms:
- 30 mg/L
Additional information
Since no studies on the toxicity to aquatic microorganisms are available a ready biodegradability study is used to derive a NOEC for the toxicity to aquatic microorganisms. If a compound degrades well in a ready biodegradability test, or does not inhibit the degradation of a positive control at a certain concentration, this concentration can be used as a NOEC value. This approach is in accordance with the Guidance on information requirements and chemical safety assessment (Chapter R.7b: Endpoint specific guidance, ECHA 2017).
A substance can be assumed to be not inhibitory to aquatic microorganisms, if in the toxicity control of a ready biodegradation test, more than 25% degradation based on [oxygen demand (BOD/ThOD)] occurred within 14 days (OECD guideline 301). For fatty acids C18-C22 (even numbered), tetraesters with pentaerythritol a biodegradation test according to OECD guideline 301F is available (Katagiri, 2018). The test includes a toxicity control, which contains 9 mg of [fatty acids C18-C22 (even numbered), tetraesters with pentaerythritol] and 30 mg/L of the reference material [e.g. sodium benzoate]. The toxicity control attained 58 % degradation after 14 days of incubation. Hence, the substance is not toxic to aquatic microorganisms in the toxicity control and the test item concentration of 30 mg/L can be used as NOEC.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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