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Diss Factsheets

Administrative data

Endpoint:
health surveillance data
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature
Justification for type of information:
For justification of Read-across / Weight-of-evidence approach, please refer to justification documentation attached in IULCID Chapter 13.
Cross-reference
Reason / purpose for cross-reference:
assessment report
Remarks:
justification for weight-of-evidence approach

Data source

Reference
Reference Type:
publication
Title:
Recommendation from the Scientific Committee on Occupational Exposure Limits for tin and inorganic tin compounds
Author:
SCOEL/SUM/97
Year:
2003
Bibliographic source:
European Commission; Employment, Social Affairs and Inclusion: Recommendation from the Scientific Committee on Occupational Exposure Limits for tin and inorganic tin compunds

Materials and methods

Study type:
biological effect monitoring
Endpoint addressed:
repeated dose toxicity: inhalation
Test guideline
Qualifier:
no guideline followed
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Tin dioxide
EC Number:
242-159-0
EC Name:
Tin dioxide
Cas Number:
18282-10-5
Molecular formula:
O2 Sn
IUPAC Name:
Tin dioxide
Specific details on test material used for the study:
workers examined were exposed to tin melting fumes or condensation aerosols formed during the melting of tin, consisting mainly of SnO2.

Method

Type of population:
occupational
Details on study design:
Study 1: Employees, including pensioners, from a tin melting works were examined and chest X-rays were taken to determine tin load of lungs. The type of work conducted was documented and the number of year the workers were working with tin was recorded. Clinical symptoms were documented and lung function studies were conducted and mortality was evaluated compared to the general population of the area (UK).

Study 2: A survey was made over a number of years of workers exposed to condensation aerosols formed during the melting of tin and consisting mainly of SnO2. Total silica concentration in the aerosols did not exceed 3%. Total dust concentration in air varied between 3 and 70 mg/m3. Appearances of pneumoconiosis were documented and set into relation of worker OEL implementation.

Results and discussion

Results:
Study 1: Chest X-ray changes were found in 121 out of 215 workers. The changes were widespread, tiny, dense shadows or softer, larger, more nodular opacities. Typical changes were found in workers handling raw ore, smelting furnace house workers and refinery furnace men. The length of employment was 3-50 years. None of the men had any clinical symptoms or signs referable to pneumoconiosis. None of the films suggested fibrosis or significant emphysema. Lung function studies showed no disability, whatever the radiographic category. The population at the tin melting works had lower mortality (131 deaths) than expected when compared to the male population in the UK (expected 166) in the period 1921-55.

Study 2: Workers developed pneumoconiosis after 6 to 8 years of employment. No cases of pneumoconiosis were observed 10 years after the dust concentration had been reduced to 10 mg/m3. No further details are given.

Applicant's summary and conclusion

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