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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1977
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1977
Report date:
1977

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Single oral dose toxicity determined by the method of Smyth et al. (1962), no details on method provided.
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Oxalic acid
EC Number:
205-634-3
EC Name:
Oxalic acid
Cas Number:
144-62-7
Molecular formula:
C2H2O4
IUPAC Name:
oxalic acid
Test material form:
solid

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
water
Doses:
Not specified
No. of animals per sex per dose:
Not specified
Control animals:
not specified
Statistics:
The LD50 and its 95% confidence limits are estimated by the moving average technique (Thompson, 1947; Weil, 1952).

Rfce:
THOMPSON, W. R. (1947). Use of moving averages and interpolation to estimate median-effective dose. I. Fundamental formulae, estimation and error, and relation to other methods: Bact.Rev. 11, 115-145.
WElL, C. S. ( 1952). Tables for convenient calculations of median-effective dose and instructions in their use. Biometrics 8, 249-263.

Results and discussion

Effect levelsopen allclose all
Sex:
male
Dose descriptor:
LD50
Effect level:
9.5 mL/kg bw
95% CL:
>= 5.4 - <= 12.3
Remarks on result:
other: 5% aqueous solution of oxalic acid
Key result
Sex:
female
Dose descriptor:
LD50
Effect level:
7.5 mL/kg bw
95% CL:
>= 5 - <= 11
Remarks on result:
other: 5% aqueous solution of oxalic acid

Applicant's summary and conclusion

Interpretation of results:
Category 4 based on GHS criteria
Conclusions:
In a single oral toxicity test with a 5% aqueous solution of oxalic acid, an LD50 of 9.5 mL/kg was determined in male rats, and an LD50 of 7.5 mL/kg was determined in female rats, under the current test conditions.
Considering a density of 0.813g/mL and the dilution into 5% aqueous solution, the LD50 considered for classification are LD50 = 386.17 in male rats, & LD50 = 304.87 in female rats.
Executive summary:

In this study, the single oral dose toxicity of 110 organic and inorganic compounds, including oxalic acid, was tested. For a 5% aqueous solution of oxalic acid, an LD50 of 9.5 mL/kg was determined in male rats, and an LD50 of 7.5 mL/kg was determined in female rats, under the current test conditions.