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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
documentation insufficient for assessment
Remarks:
The study predates GLP and the description of method is not provided.

Data source

Reference
Reference Type:
publication
Title:
Studies on the Toxicity of Phthalates via Ingestion
Author:
Krauskopf L G
Year:
1973
Bibliographic source:
Environmental Health Perspectives 3:61-72.

Materials and methods

Principles of method if other than guideline:
- Principle of test: Rats given single doses of DUP of up to at least 15.8 g/kg bw.
- Short description of test conditions: No data on test method.
- Parameters analysed / observed: Animals observed for signs of toxicity.
GLP compliance:
no
Test type:
other: No data
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Diundecyl phthalate
EC Number:
222-884-9
EC Name:
Diundecyl phthalate
Cas Number:
3648-20-2
Molecular formula:
C30H50O4
IUPAC Name:
1,2-diundecyl benzene-1,2-dicarboxylate

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Doses:
up to at least 15.8 g/kg bw
No. of animals per sex per dose:
no data
Control animals:
not specified

Results and discussion

Effect levels
Key result
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 15 800 mg/kg bw
Based on:
test mat.
Mortality:
No mortality occurred during the study.
Clinical signs:
other: No significant toxic effects

Applicant's summary and conclusion

Interpretation of results:
other: Not classified (CLP Regulation EC no. 1272/2008)
Conclusions:
The acute oral LD50 value of the test substance is higher than 15.8 g/kg bw in rats.
Executive summary:

A single dose toxicity study was conducted with DUP in rats up to at least 15.8 g/kg bw. No mortalities were reported. Under the conditions of this study DUP was considered practically non-toxic. Thus, it can be concluded that the acute oral LD50 value of the test substance is higher than 15.8 g/kg bw in rats.