Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 222-884-9 | CAS number: 3648-20-2
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
- Remarks:
- The study predates GLP and the description of method is not provided.
Data source
Reference
- Reference Type:
- publication
- Title:
- Studies on the Toxicity of Phthalates via Ingestion
- Author:
- Krauskopf L G
- Year:
- 1 973
- Bibliographic source:
- Environmental Health Perspectives 3:61-72.
Materials and methods
- Principles of method if other than guideline:
- - Principle of test:
Rats given single doses of DUP of up to at least 15.8 g/kg bw.
- Short description of test conditions: No data on test method.
- Parameters analysed / observed: Animals observed for signs of toxicity. - GLP compliance:
- no
- Test type:
- other: No data
- Limit test:
- no
Test material
- Reference substance name:
- Diundecyl phthalate
- EC Number:
- 222-884-9
- EC Name:
- Diundecyl phthalate
- Cas Number:
- 3648-20-2
- Molecular formula:
- C30H50O4
- IUPAC Name:
- 1,2-diundecyl benzene-1,2-dicarboxylate
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Doses:
- up to at least 15.8 g/kg bw
- No. of animals per sex per dose:
- no data
- Control animals:
- not specified
Results and discussion
Effect levels
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 15 800 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality occurred during the study.
- Clinical signs:
- other: No significant toxic effects
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified (CLP Regulation EC no. 1272/2008)
- Conclusions:
- The acute oral LD50 value of the test substance is higher than 15.8 g/kg bw in rats.
- Executive summary:
A single dose toxicity study was conducted with DUP in rats up to at least 15.8 g/kg bw. No mortalities were reported. Under the conditions of this study DUP was considered practically non-toxic. Thus, it can be concluded that the acute oral LD50 value of the test substance is higher than 15.8 g/kg bw in rats.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
