2-[10-(acetyloxy)-9a,11a-dimethyl-7-oxo-3H,3aH,3bH,4H,5H,7H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-1-yl]-2-oxoethyl acetate

Vapour pressure

Administrative data

Endpoint:

vapour pressure

Type of information:

experimental study

Adequacy of study:

key study

Study period:

from 15 January 2018 to 01 May 2018

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2018

Report date:

2018

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

EU Method A.4 (Vapour Pressure)

Version / remarks:

2016

Deviations:

no

Test guideline 2

Qualifier:

according to guideline

Guideline:

OECD Guideline 104 (Vapour Pressure Curve)

Version / remarks:

2006

Deviations:

no

Test guideline 3

Qualifier:

according to guideline

Guideline:

EPA OPPTS 830.7950 (Vapor Pressure)

Version / remarks:

1996

Deviations:

no

GLP compliance:

yes

Type of method:

effusion method: isothermal thermogravimetry

Test material

Test material information

Constituent 1

Reference substance name:

2-[10-(acetyloxy)-9a,11a-dimethyl-7-oxo-3H,3aH,3bH,4H,5H,7H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-1-yl]-2-oxoethyl acetate

EC Number:

607-277-2

Cas Number:

23825-05-0

Molecular formula:

C25H30O6

IUPAC Name:

2-[10-(acetyloxy)-9a,11a-dimethyl-7-oxo-3H,3aH,3bH,4H,5H,7H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-1-yl]-2-oxoethyl acetate

Test material form:

solid: particulate/powder

Details on test material:

- Appearance: Off-white powder
- Storage condition of test material: At room temperature

Specific details on test material used for the study:

Decomposition temp.: 300°C

Results and discussion

Vapour pressure

Vapour pressure 1

Key result

Temp.:

20 °C

Vapour pressure:

< 0 Pa

Vapour pressure 2

Key result

Temp.:

25 °C

Vapour pressure:

< 0 Pa

Any other information on results incl. tables

Table: Results of the isothermal TGA analysis (test item)

Temperature [°C]	Weight loss [µg/min]	νT [g/cm^2/h]	logνT	log PT	PT [Pa]
200	0.588981	7.03E-5	-4.15	-0.18	0.66
	0.544942	6.50E-5	-4.19	-0.22	0.60
210	1.28159	1.53E-4	-3.82	0.25	1.8
	1.16354	1.39E-4	-3.86	0.20	1.6
220	2.80806	3.35E-4	-3.47	0.69	4.9
	2.61002	3.12E-4	-3.51	0.65	4.5

Extrapolation of the curve to 20°C or 25°C resulted in values outside the validated range of the method (4.3E-14 Pa and 1.6E-13 Pa, resp.).

Since the weight loss of the test item at 200°C, 210°C and 220°C was lower than the weight loss of reference substance benzo(ghi)perylene at the same temperatures, it was assumed that the vapour pressure of the substance at 20°C (25°C) is lower than the vapour pressure of benzo(ghi)perylene at 20°C (25°C).

Applicant's summary and conclusion

Conclusions:

The vapour pressure of the substance at 20°C and 25°C was determined to be <1.3E-8 Pa and <7.2E-8 Pa, resp.

Executive summary:

The vapour pressure of the substance was determined using the isothermal thermogravimetric effusion method in a GLP study according to EC A.4, OECD 104 and OPPTS 830.7950. A vapour pressure curve was constructed from 5 reference substances. Extrapolation of the curve to 20°C or 25°C resulted in values below the validated range of the method. As the vapour pressure of the substance at the test temperatures was determined to be lower than that of reference substance benzo(ghi)perylene at the same temperatures, it was assumed that the vapour pressure of the substance at 20°C (25°C) is lower than the vapour pressure of benzo(ghi)perylene at 20°C (25°C). The vapour pressure of the substance at 20°C and 25°C was concluded to be <1.3E-8 Pa and <7.2E-8 Pa, resp.