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Short-term toxicity to aquatic invertebrates

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Reference
Endpoint:
short-term toxicity to aquatic invertebrates
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2017
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
other: ISO 14669:1999 “Water quality - Determination of acute lethal toxicity to marine copepods (Copepoda, Crustacea)”
GLP compliance:
yes
Test organisms (species):
other: Acartia tonsa
Test type:
static
Water media type:
saltwater
Total exposure duration:
48 h
Test temperature:
20.0 – 20.5°C
pH:
7.54 – 7.99
Dissolved oxygen:
4.89 – 8.02 mgL
Salinity:
31‰
Duration:
24 h
Dose descriptor:
LL50
Effect conc.:
42.05 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality
Remarks on result:
other: Statistical methods used in ToxCalc v5.0: Trimmed Spearman-Karber (Trim 40.0%)
Duration:
48 h
Dose descriptor:
LL10
Effect conc.:
6.928 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality
Remarks on result:
other: Statistical methods used in ToxCalc v5.0: Maximum Likelihood-Probit
Key result
Duration:
48 h
Dose descriptor:
LL50
Effect conc.:
17.96 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality
Remarks on result:
other: Statistical methods used in ToxCalc v5.0: Maximum Likelihood-Probit
Key result
Duration:
48 h
Dose descriptor:
NOELR
Effect conc.:
6.2 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality
Validity criteria fulfilled:
yes
Conclusions:
The 24-hour and 48-hour LL50 of OXIDIZED FATTY ACIDS to Acartia tonsa were 42.05mg/l and 17.96 mg/l respectively (determined by Trimmed Spearman-Karber and Maximum Likelihood-Probit).
The 48-hour NOELR and LOELR were 6.2mg/l and 12.5mg/l respectively (Determined by Steel’s Many One Rank Test, 1-tail, P=0.05).

Description of key information

Key value for chemical safety assessment

Marine water invertebrates

Marine water invertebrates
Effect concentration:
17.96 mg/L

Additional information