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EC number: 451-620-7 | CAS number: 352230-22-9
28-day LC50: >4074 mg/kg dry weight and 56-day NOEC ≥4074 mg/kg dry weight, for the effects of D5 on mortality and reproduction and growth, respectively, of Eisenia andrei.
28-day LC50: >41 mg/kg dry weight and 56-day NOEC ≥41 mg/kg dry weight (measured concentrations), for the effects of D5 on survival and reproduction, respectively, of Eisenia fetida.
There are currently no reliable data describing the long-term toxicity of the registered substance to soil macroorganisms.
An OECD TG 222 earthworm reproduction test is being conducted with the registration substance according to ECHA final decision TPE-D-2114497761-36-01/F. The substance dataset and risk assessment will be updated once results of the study are available and the study is finalised. An update is planned to be completed within three months from when the last final report is received. The final test report is expected in March 2021. Please see a letter from the testing laboratory, attached in Section 6.3.1 IUCLID Placeholder EPSR, for further details.
In the interim period, before the data with the registered substance become available, data are read across from the siloxane decamethylcyclopentasiloxane (D5, CAS 541-02-6).
A 28-day LC50 value of >4074 mg/kg dry weight and a 56-day NOEC of ≥4074 mg/kg dry weight (measured initial concentration) have been determined for the effects of the test substance on mortality and reproduction and growth respectively of Eisenia andrei (Velicogna et al., 2011).
No effects at the highest concentration tested were also determined in a second test with D5: 28-d F0 LC50 values of >76 mg/kg nominal concentration, >41 mg/kg mean measured concentration, and NOECs of 76 mg/kg nominal concentration, and 41 mg/kg mean measured concentration, have been determined for effects of D5 on survival and weight change of adult earthworms.
56-d F1 LC50 values of >76 mg/kg nominal concentration, >41 mg/kg mean measured concentration, and NOECs of 76 mg/kg nominal concentration, and 41 mg/kg mean measured concentration, have been determined for effects of D5 on reproduction of the earthworm Eisenia fetida (Smithers Viscient, 2015).
Read-across of the terrestrial toxicity data for D5 to Reaction Mass of 3,3-diphenylhexamethyltrisiloxane and 3,3,5,5-tetraphenylhexamethyltetrasiloxane (CAS 352230-22-9) is considered to be suitable to derive an interim hazard and risk assessment under REACH until the studies with the registration substance are available.
Refer to IUCLID Sections 6.0 and 6.3 (CSR Sections 7.0 and 7.2) for further discussion.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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