Registration Dossier
Registration Dossier
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EC number: 211-949-7 | CAS number: 719-59-5
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 2-amino-5-chlorobenzophenone
- EC Number:
- 211-949-7
- EC Name:
- 2-amino-5-chlorobenzophenone
- Cas Number:
- 719-59-5
- Molecular formula:
- C13H10ClNO
- IUPAC Name:
- (2-amino-5-chlorophenyl)(phenyl)methanone
- Test material form:
- solid: particulate/powder
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Vehicle:
- unchanged (no vehicle)
- Amount / concentration applied:
- 0.1 g of the test item was instilled into the conjunctival sac of one eye. The other eye remained untreated serving as control.
- Observation period (in vivo):
- 1h
- Number of animals or in vitro replicates:
- 3
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- other: Individual irritation index
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- fully reversible
- Irritation parameter:
- other: individual irritation index
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- fully reversible
- Irritation parameter:
- other: individual irritation index
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- fully reversible
- Irritant / corrosive response data:
- The ocular reactions observed during the study have been slight to moderate and totally reversible.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The eye irritation potential was determined according to the OECD 405 guideline. The ocular reactions observed during the study have been slight to moderate and totally reversible. The study concludes that the test item does not have to be classified.
- Executive summary:
The eye irritation potential was determined according to the OECD 405 guideline. The ocular reactions observed during the study have been slight to moderate and totally reversible. The study concludes that the test item does not have to be classified.
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