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EC number: 257-765-0 | CAS number: 52234-82-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
- Remarks:
- no detailed information on conduct of the study available; purity of the test substance not specified
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 977
- Report date:
- 1977
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- - Principle of test:
The test substance was applied via stomach intubation (single dose). No further details on the conduct of the study available.
- Short description of test conditions: no information availble
- Parameters analysed / observed: mortality, clinical signs, body weight changes, gross pathology of died animals and survivors - GLP compliance:
- no
Test material
- Reference substance name:
- Pentaerythritol tris(3-aziridin-1-ylpropionate)
- EC Number:
- 260-568-2
- EC Name:
- Pentaerythritol tris(3-aziridin-1-ylpropionate)
- Cas Number:
- 57116-45-7
- Molecular formula:
- C20H33N3O7
- IUPAC Name:
- 3-[(3-aziridin-1-ylpropanoyl)oxy]-2-{[(3-aziridin-1-ylpropanoyl)oxy]methyl}-2-(hydroxymethyl)propyl 3-aziridin-1-ylpropanoate (non-preferred name)
Constituent 1
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Lot/batch No. of test material: 03788
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: testing facility
- Age at study initiation: 3 - 4 weeks
- Weight at study initiation: 90 - 120 g
- Fasting period before study: no
- Diet: Wayne diet, ad libitum
- Water: ad libitum
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- MAXIMUM DOSE VOLUME APPLIED: 8 mL/kg bodyweight
- Doses:
- 8, 4 and 2 mL/kg body weight (corresponding to approx. 9264, 4632 and 2316 mg/kg body weight; based on a density of 1.158 g/mL (lit.))
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: not specified
- Frequency of observations and weighing: not specified
- Necropsy of survivors performed: yes + necropsy of died animals
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 4.92 mL/kg bw
- Remarks on result:
- other: corresponding to approx. 5697 mg/kg bodyweight (based on the density of 1.158 g/mL (lit.))
- Mortality:
- - in the 8 mL/kg bw group 5/5 animals died (4 on 1st day and 1 after 5 days)
- in the 4 mL/kg bw group 1/5 animals died (on 1st day)
- in the 2 mL/kg bw group no mortality was observed - Clinical signs:
- other: - 8 mL/kg bw group: sluggish, slow breathing 15 min; prostrate 1.5 h - 4 mL/kg bw group: sluggish, slow breathing 30 min; piloerection, legs stiffened within 2 h; prostrate at 2.5 h; convulsions, foaming at mouth at 4 h - 2 mL/kg bw group: sluggish, slow
- Gross pathology:
- - in died animals petechial hemorrhages and congestion in the lungs; livers burned; livers, spleens and kidneys mottled; kidneys pale; adrenals congested; stomachs distended, containing a hard mass, opaque and gas-filled; intestines opaque, gas-filled and yellow
- nothing remarkable in survivors
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
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