Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Short-term toxicity to fish

Currently viewing:

Administrative data

Link to relevant study record(s)

Description of key information

A static test with zebrafish (OECD 203) indicated no mortality at 1000 mg/L after 96 hour.

Key value for chemical safety assessment

Fresh water fish

Fresh water fish
Effect concentration:
1 000 mg/L

Additional information

The test substance is covered by the category approach of methylenediphenyl diisocyanates (MDI). Hence, data of the category substances can be used to cover this endpoint. Two short-term aquatic toxicity studies are available for fish for polymeric MDI (CAS 9016-87-9). In a study with Oryzias latipes (Nakata, 1982), no acute toxicity was observed after 96h exposure to 3000 mg/L (semi-static). ). The Nichi-Nou-Sei B2735 (1965) protocol was followed, which is similar to OECD 203. A static test with Danio rerio (OECD 203) gave no mortality at 1000 mg/L, which was the highest concentration tested (Caspers, 1986). This value may be considered for the derivation of a PNECaqua. A third fish study with Danio rerio is available, but lacks some critical information. Hence it is classified as unreliable. The 24h-EC50 was determined to be > 500 mg/L. Based on the justification in the category approach of methylenediphenyl diisocyanates (MDI), it is assumed that all MDI analogues included in the category have a similar fish toxicity.