4,4'-methylenediphenyldiisocyanate and 2,4'-diisocyanatodiphenylmethane and their oligomerisation reaction products with 2,2'-oxydiethanol, propane-1,2-diol and butane-1,3-diol

Endpoint summary

Additional information

The test substance is covered by the category approach of methylenediphenyl diisocyanates (MDI). Hence, data of the category substances can be used to cover this endpoint. The read-across category justification document is attached in IUCLID section 13. It is important to note that the MDI category approach for read-across of environmental and human hazards between the MDI substances belonging to the MDI category is work in progress under REACH. Therefore the read-across document should be considered a draft.

Two separate short-term toxicity studies (van der Hoeven et al, 1992) are available with terrestrial organisms for polymeric MDI. For the earthworm Eisenia fetida, tested according to OECD 207, a 14d-EC50 of 1000 mg/kg soil (d.w.) was obtained. For the plants Avena sativa and Lactuca sativa, tested according to OECD 208, 14d-EC50 of 1000 mg/kg soil (d.w.) values were obtained. The values may be considered for the derivation of a PNEC soil.