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The test substance is covered by the category approach of methylenediphenyl diisocyanates (MDI). Hence, data of the category substances can be used to cover this endpoint. The read-across category justification document is attached in IUCLID section 13. It is important to note that the MDI category approach for read-across of environmental and human hazards between the MDI substances belonging to the MDI category is work in progress under REACH. Therefore the read-across document should be considered a draft.

Two separate short-term toxicity studies (van der Hoeven et al, 1992) are available with terrestrial organisms for polymeric MDI. For the earthworm Eisenia fetida, tested according to OECD 207, a 14d-EC50 of 1000 mg/kg soil (d.w.) was obtained. For the plants Avena sativa and Lactuca sativa, tested according to OECD 208, 14d-EC50 of 1000 mg/kg soil (d.w.) values were obtained. The values may be considered for the derivation of a PNEC soil.