Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Endpoint summary

Administrative data

Description of key information

Additional information

The test substance is covered by the category approach of methylenediphenyl diisocyanates (MDI). Hence, data of the category substances can be used to cover this endpoint. The read-across category justification document is attached in IUCLID section 13. It is important to note that the MDI category approach for read-across of environmental and human hazards between the MDI substances belonging to the MDI category is work in progress under REACH. Therefore the read-across document should be considered a draft.

Two separate short-term toxicity studies (van der Hoeven et al, 1992) are available with terrestrial organisms for polymeric MDI. For the earthworm Eisenia fetida, tested according to OECD 207, a 14d-EC50 of 1000 mg/kg soil (d.w.) was obtained. For the plants Avena sativa and Lactuca sativa, tested according to OECD 208, 14d-EC50 of 1000 mg/kg soil (d.w.) values were obtained. The values may be considered for the derivation of a PNEC soil.