Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2014
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study without detailed documentation
Remarks:
The study was conducted with reference to an internationally recognised method, but no information is provided on actual test conditions. The test substance is adequately characterised, but information on composition is incomplete. Therefore validation applies with restrictions.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Report date:
2014

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
Version / remarks:
13th April 2004
Qualifier:
according to guideline
Guideline:
EU Method A.8 (Partition Coefficient - HPLC Method)
Version / remarks:
Regulation (EC) No 440/2008
GLP compliance:
no
Type of method:
HPLC method
Partition coefficient type:
octanol-water

Test material

Constituent 1
Chemical structure
Reference substance name:
(4Z,8E)-13-oxabicyclo[10.1.0]trideca-4,8-diene
EC Number:
951-761-9
Cas Number:
55722-64-0
Molecular formula:
C12H18O
IUPAC Name:
(4Z,8E)-13-oxabicyclo[10.1.0]trideca-4,8-diene
Test material form:
liquid
Details on test material:
Physical state: Clear colourless liquid

Study design

Analytical method:
high-performance liquid chromatography

Results and discussion

Partition coefficient
Key result
Type:
log Pow
Partition coefficient:
3.39
Temp.:
25 °C
pH:
ca. 0 - ca. 14

Any other information on results incl. tables

Temperature and pH are not specified in the report.

However, HPLC for logKow determinations is generally run at moderate temperatures, and no high temperature dependency is expected.

Similarly, based on chemical structure, no ionisation, therefore no pH dependency, is anticipated either.

Applicant's summary and conclusion

Conclusions:
The substance has low potential to bioaccumulate in the environment, according to CLP classification criteria for aquatic chronic toxicity (log Kow <4).
Executive summary:

The partition coefficient of the test substance was measured (non-GLP) according to the OECD 117/EU A8 guideline, HPLC method.

No experimental details are provided in the report.

The partition coefficient (log Kow) of the test substance has been determined to be 3.39.