Registration Dossier
Registration Dossier
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EC number: - | CAS number: -
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 011
- Report date:
- 2011
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- GLP compliance:
- no
Test material
- Reference substance name:
- Silybum marianum extract
- Molecular formula:
- Not applicable
- IUPAC Name:
- Silybum marianum extract
- Test material form:
- liquid
- Details on test material:
- The test matérial contains 0.5% of tocophérol for stability
1
Test solutions
- Vehicle:
- no
Test organisms
- Test organisms (species):
- Daphnia magna
Study design
- Test type:
- not specified
- Water media type:
- not specified
- Limit test:
- no
- Total exposure duration:
- 48 h
Test conditions
- Hardness:
- not specified
- Test temperature:
- 20 °C
- pH:
- 7.9
- Dissolved oxygen:
- 9.2 mg/L
- Salinity:
- not specified
- Conductivity:
- not specified
- Reference substance (positive control):
- yes
- Remarks:
- potassium dichromate
Results and discussion
Effect concentrations
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- ca. 17.6 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- not specified
- Basis for effect:
- mobility
- Details on results:
- 95% confidence interval : 15.30 - 20.17 mg/L
- Results with reference substance (positive control):
- Valid
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- The result obtained for EC50 is 17.60 mg / L.
- Executive summary:
The objective of this work is the determination of acute toxicity of LIPOLAMI milk thistle ER on aquatic invertebrates according OECD 202 method.
The result obtained for EC50 is 17.60 mg / L.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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