Registration Dossier
Registration Dossier
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EC number: 213-126-8 | CAS number: 925-83-7
Water solubility
Administrative data
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 13 Aug 2018 - 16 Oct 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Cross-reference
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- 1995
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Version / remarks:
- 2016
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7840 (Water Solubility)
- Version / remarks:
- 1998
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- flask method
Test material
- Reference substance name:
- Sebacohydrazide
- EC Number:
- 213-126-8
- EC Name:
- Sebacohydrazide
- Cas Number:
- 925-83-7
- Molecular formula:
- C10H22N4O2
- IUPAC Name:
- sebacohydrazide
- Test material form:
- solid: particulate/powder
- Details on test material:
- Test item name (as stated in report): SDH
Test item storage: at room temperature protected from light
Constituent 1
Results and discussion
Water solubility
- Key result
- Water solubility:
- 0.208 g/L
- Conc. based on:
- test mat. (dissolved fraction)
- Loading of aqueous phase:
- 0.975 g/L
- Incubation duration:
- >= 24 - <= 72 h
- Temp.:
- 20 °C
- pH:
- >= 8.4 - <= 8.5
- Details on results:
- - Concentration analysed after 24, 48 and 72 hours of stirring: 0.210 g/L, 0.208 g/L and 0.206 g/L, resp.
- Maximum difference meets the criterion of ≤ 15% (i.e. 1.7%)
- The mean of the three concentrations was reported as the water solubility of the substance.
Any other information on results incl. tables
A small response at the retention time of the test item was detected in the chromatogram of the pretreated sample from the blank water mixture. The response was lower than the intercept of the calibration curve and no concentration could be calculated. As the response was so low, it was considered to have no impact on the study results.
Applicant's summary and conclusion
- Conclusions:
- The water solubility of the substance at 20°C was determined to be 0.208 g/L (flask method).
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