3-fluoro-4'-(trans-4-propylcyclohexyl)-1,1'-biphenyl

Short-term toxicity to aquatic invertebrates

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

short-term toxicity to aquatic invertebrates

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

comparable to guideline study

Justification for type of information:

For this endpoint information from structural similar compounds (CAS 132123-39-8) is available. The studies for these similar compounds were performed according to GLP and the methods applied are fully compliant with OECD TG 211. See chapter 13 report for a more detailed justification.

Reason / purpose for cross-reference:

read-across source

Reason / purpose for cross-reference:

reference to same study

Key result

Duration:

48 h

Dose descriptor:

EC50

Effect conc.:

> 100 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mobility

Reference 2

Endpoint:

short-term toxicity to aquatic invertebrates

Type of information:

experimental study

Adequacy of study:

key study

Study period:

April 18, 2013 - February 19, 2014

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

comparable to guideline study

Reason / purpose for cross-reference:

reference to other study

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)

Version / remarks:

Non GLP preliminary Range Finding Test as part of OECD Guideline 211

GLP compliance:

no

Remarks:

Non GLP preliminary Range Finding Test as part of OECD Guideline 211

Analytical monitoring:

no

Test organisms (species):

Daphnia magna

Test type:

static

Water media type:

freshwater

Limit test:

yes

Total exposure duration:

48 h

Nominal and measured concentrations:

nominal: 100 mg/L

Details on test conditions:

TEST SYSTEM
- No. of organisms per vessel: n = 20 per concentration, divided into 2 replicates with 10 daphnids each
- No. of vessels per concentration (replicates): 2
- No. of vessels per control (replicates): 2

EFFECT PARAMETERS MEASURED (with observation intervals if applicable) : Immobilisation after 24 h and 48 h

Key result

Duration:

48 h

Dose descriptor:

EC50

Effect conc.:

> 100 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mobility

Validity criteria fulfilled:

not applicable

Conclusions:

A non GLP preliminary range finding test was carried out at the test facility as acute immobilisation test to Daphnia magna STRAUS. A limit loading rate of 100 mg/L of the test item was tested under static conditions over a period of 48 h. No adverse effects on the mobility of Daphnia magna were observed after 24 h and 28 h, respectively. Thus, the 48 h EC50 of the test item analogue is considered to be greater that 100 mg/L (nominal)

Description of key information

A non GLP preliminary range finding test was carried out at the test facility as acute immobilisation test to Daphnia magna STRAUS. A limit loading rate of 100 mg/L of the test item analogue was tested under static conditions over a period of 48 h. No adverse effects on the mobility of Daphnia magna were observed after 24 h and 28 h, respectively. Thus, the 48 h EC50 of the test item analogue is considered to be greater that 100 mg/L (nominal)