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Short-term toxicity to aquatic invertebrates

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Endpoint:
short-term toxicity to aquatic invertebrates
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
comparable to guideline study
Justification for type of information:
For this endpoint information from structural similar compounds (CAS 132123-39-8) is available. The studies for these similar compounds were performed according to GLP and the methods applied are fully compliant with OECD TG 211. See chapter 13 report for a more detailed justification.
Reason / purpose for cross-reference:
read-across source
Reason / purpose for cross-reference:
reference to same study
Key result
Duration:
48 h
Dose descriptor:
EC50
Effect conc.:
> 100 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mobility
Endpoint:
short-term toxicity to aquatic invertebrates
Type of information:
experimental study
Adequacy of study:
key study
Study period:
April 18, 2013 - February 19, 2014
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
comparable to guideline study
Reason / purpose for cross-reference:
reference to other study
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
Version / remarks:
Non GLP preliminary Range Finding Test as part of OECD Guideline 211
GLP compliance:
no
Remarks:
Non GLP preliminary Range Finding Test as part of OECD Guideline 211
Analytical monitoring:
no
Test organisms (species):
Daphnia magna
Test type:
static
Water media type:
freshwater
Limit test:
yes
Total exposure duration:
48 h
Nominal and measured concentrations:
nominal: 100 mg/L
Details on test conditions:
TEST SYSTEM
- No. of organisms per vessel: n = 20 per concentration, divided into 2 replicates with 10 daphnids each
- No. of vessels per concentration (replicates): 2
- No. of vessels per control (replicates): 2

EFFECT PARAMETERS MEASURED (with observation intervals if applicable) : Immobilisation after 24 h and 48 h

Key result
Duration:
48 h
Dose descriptor:
EC50
Effect conc.:
> 100 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mobility
Validity criteria fulfilled:
not applicable
Conclusions:
A non GLP preliminary range finding test was carried out at the test facility as acute immobilisation test to Daphnia magna STRAUS. A limit loading rate of 100 mg/L of the test item was tested under static conditions over a period of 48 h. No adverse effects on the mobility of Daphnia magna were observed after 24 h and 28 h, respectively. Thus, the 48 h EC50 of the test item analogue is considered to be greater that 100 mg/L (nominal)

Description of key information

A non GLP preliminary range finding test was carried out at the test facility as acute immobilisation test to Daphnia magna STRAUS. A limit loading rate of 100 mg/L of the test item analogue was tested under static conditions over a period of 48 h. No adverse effects on the mobility of Daphnia magna were observed after 24 h and 28 h, respectively. Thus, the 48 h EC50 of the test item analogue is considered to be greater that 100 mg/L (nominal)

Key value for chemical safety assessment

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