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Toxicological information

Basic toxicokinetics

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Administrative data

Endpoint:
basic toxicokinetics in vitro / ex vivo
Type of information:
other: review article
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
secondary literature

Data source

Reference
Reference Type:
review article or handbook
Title:
Coordination compounds in medicinal chemistry
Author:
Chad W. Schwietert, John P. McCue
Year:
1999
Bibliographic source:
Coordination Chemistry Reviews 184 67–89

Materials and methods

Objective of study:
other: review article
Principles of method if other than guideline:
A review of work involving the development of Fe(II), Pt(II), and Ti(IV) complexes as pharmaceuticals, and what this work reveals about transport of metal compounds across cell membranes

Results and discussion

Applicant's summary and conclusion

Executive summary:

This review covers the early uses of titanium (IV) compounds to treat topical infections, investigations into anti-tumour activity, effects on proteases, and effects on bacteria. The article also provides a review of titanium (IV) transport into cells. Studies in both man and in animals given titanium (IV) compounds through the orak route, and via i.p and i.m. injection have shown titanium may be taken up into lungs, liver, kidney, heart and spleen.