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EC number: 402-370-2 | CAS number: 149057-70-5 AOC 1020X
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1987
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Report date:
- 1987
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- Version / remarks:
- Safepharm Standard Test Method M26 based on the following publications:
1. Ames, B.N., Durson, W.E., Yamasaki, E., and Lee, F . D. Proc. Nat. Acad.Sci. USA (1970), 70, 22B5
2. Ames, B.N. , Mccann, J. and Yamasake, E., Mutation Research (1975), 31, 347.
3. McCann, J., Coi, E., Yamasaki, E., and f'l!les, B.N. Proc. Nat. Acad. Sci. USA (1975) 75, 5135. - Deviations:
- not specified
- GLP compliance:
- yes
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- (ethyl-3-oxobutanoato-O'1,O'3)(2-dimethylaminoethanolato)(1-methoxypropan-2-olato)aluminium(III), dimerised
- EC Number:
- 402-370-2
- EC Name:
- (ethyl-3-oxobutanoato-O'1,O'3)(2-dimethylaminoethanolato)(1-methoxypropan-2-olato)aluminium(III), dimerised
- Cas Number:
- 149057-70-5
- Molecular formula:
- C14H28AlNO6
- IUPAC Name:
- octaaluminium(3+) octakis((2Z)-4-ethoxy-4-oxobut-2-en-2-olate) octakis(1-methoxypropan-2-olate) octakis(2-(dimethylamino)ethan-1-olate)
- Reference substance name:
- 1-methoxypropan-2-ol
- EC Number:
- 203-539-1
- EC Name:
- 1-methoxypropan-2-ol
- Cas Number:
- 107-98-2
- Molecular formula:
- C4H10O2
- IUPAC Name:
- 1-methoxypropan-2-ol
- Test material form:
- liquid
- Details on test material:
- purified with vacum distillation, analyzed by Gel permeation chromatography as stated in one of the study reports
Constituent 1
impurity 1
Method
- Target gene:
- histidine
Species / strain
- Species / strain / cell type:
- S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
- Details on mammalian cell type (if applicable):
- derived from salmonella T. LT2, supplied by Pr. Ames
- Metabolic activation:
- with and without
- Metabolic activation system:
- S9 fraction is obtained from animals pre-treated with Arochlor 1254 (a mixture of polychlorinated biphenyls) and was stated to be from protein level 37.l mg/ml.
- Test concentrations with justification for top dose:
- 12500 / 2500 / 500 / 100 / 20 µg/plate
- Vehicle / solvent:
- acetone
Controlsopen allclose all
- Untreated negative controls:
- no
- Remarks:
- see solvent control
- Negative solvent / vehicle controls:
- yes
- True negative controls:
- no
- Positive controls:
- yes
- Positive control substance:
- 9-aminoacridine
- N-ethyl-N-nitro-N-nitrosoguanidine
- other: 4 Nitro-0-phenyldiamine
- Positive controls:
- yes
- Positive control substance:
- other: 2-aminoanthracene
- Evaluation criteria:
- For a substance to be considered positive in this test system, it should have induced a dose-'related and statisically significant increase in mutation rate (of at least twice the spontaneous reversion rate) in one or more strains of bacteria in the presence and/or absence of the S-9 microsomal enzymes. To be considered negative the number of induced revertants compared to spontaneous revertants should be less than twofold at all dose levels employed, the intervals of which should be between
3 and 5 fold and extend to the limits imposed by toxicity or solubility. - Statistics:
- not specified
Results and discussion
Test resultsopen allclose all
- Key result
- Species / strain:
- S. typhimurium TA 1535
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- valid
- Untreated negative controls validity:
- not examined
- Positive controls validity:
- valid
- Key result
- Species / strain:
- S. typhimurium TA 1537
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- valid
- Untreated negative controls validity:
- not examined
- Positive controls validity:
- valid
- Key result
- Species / strain:
- S. typhimurium TA 1538
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- valid
- Untreated negative controls validity:
- not examined
- Positive controls validity:
- valid
- Key result
- Species / strain:
- S. typhimurium TA 98
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- valid
- Untreated negative controls validity:
- not examined
- Positive controls validity:
- valid
- Key result
- Species / strain:
- S. typhimurium TA 100
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- valid
- Untreated negative controls validity:
- not examined
- Positive controls validity:
- valid
- Additional information on results:
- solvent control is negative control
Any other information on results incl. tables
a) Preliminary Toxicity Study
The zones of inhibition observed for each tester strain and for each concentration of SA2/1/0A were scored as being+, + or - for bacteriostatic/ bactericidal activity. There was no evidence of toxicity at any of the concentrations of the test material and the main mutation studies were carried out using SA2/1/0A at concentrations in the range 20 ug/plate to 12,500 ug/plate.
b) Mutation Study
The results for the checks on viability and spontaneous reversion rate for each tester strain are shown in Table 2. The overnight culture of each strain was found to be in the required range of 108 to 109 bacteria per ml and the spontaneous reversion rate for each was found to be within the expected range. Individual plate counts together with the mean number of revertant colonies obtained for each tester strain following incubation with the test material, with and without metabolic activation.
No significant increase in the nunber of revertant colonies was recorded for any of the strains at any of the dose levels employed in this study, either with or without metabolic activation. All counts of revertant colonies were similar to those recorded for the negative control plates and were within the range expected for spontaneous reversion for each strain . The positive control substances all produced marked increases in the number of revertant colonies and the activity of the S-9 fraction was found to be satisfactory.
Applicant's summary and conclusion
- Conclusions:
- The test material , SA2/1/OA was found to exhibit no evidence of mutagenic activity under the conditions of this experiment
- Executive summary:
In an ames test which protocol is similar to OECD 471 guidelines, the test material , SA2/l/OA was found to exhibit no evidence of mutagenic activity under the conditions of this experiment.
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