Registration Dossier
Registration Dossier
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EC number: 237-731-1 | CAS number: 13951-70-7
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
Prednisolone was found to be of very low toxicity to green algae with a Fresh Water Algal Growth Inhibition Test (ISO 8692) giving a 72h-NOECof 160 mg/L . The QSAR prediction for 16alpha-hydroxyprednisolone was 96h-EC50 of 272.731 mg/L
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 272.731 mg/L
- EC10 or NOEC for freshwater algae:
- 160 mg/L
Additional information
The potential of 16alpha-hydroxyprednisolone to toxic to aquatic algae was assessed in an algal growth inhibition Test performed according to the ISO 8692 guideline (Water Quality - Fresh Water Algal Growth Inhibition Test with Scenedesmus subspicatus and Selenastrum capricornutum) with prednisolone, an analogue of 16alpha-hydroxyprednisolone. This read across approach was supported by QSAR prediction of the toxity of 16alpha-hydroxyprednisolone to green algae using the ECOSAR V1.00 (2 February 2009).
Based on the study and the ECOSAR predictions, 16alpha-hydroxyprednisolone is deemed to be of very low toxicity to green algae.
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