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Dissociation constant

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Reference
Endpoint:
dissociation constant
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2 July 2002 - 22 August 2002
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 112 (Dissociation Constants in Water)
Deviations:
no
GLP compliance:
not specified
Specific details on test material used for the study:
- Batch: V840-413
- Purity: 99.7%
- Expiry date: July 2002
- Storage conditions: room temperature (10-30°C)
Dissociating properties:
yes
No.:
#1
pKa:
5.818
Temp.:
25 °C
Remarks on result:
other: MeOH content: 49.73 (%w/v)
No.:
#2
pKa:
6.037
Temp.:
25 °C
Remarks on result:
other: MeOH content: 41.41 (%w/v)
No.:
#3
pKa:
6.158
Temp.:
25 °C
Remarks on result:
other: MeOH content: 30.88 (%w/v)

The dissociation constant of imazalil sulphate was evaluated at 25°C using pH-metric titration to be 6.54 ± 0.04.

Conclusions:
The dissociation constant of the test item was evaluated at 25°C using pH-metric titration to be 6.54 ± 0.04.

Description of key information

Based on a key study (K1, Bates, 2002) according to OECD guideline 112, the dissociation constant of the test item was determined to be 6.54 ± 0.04 at 25°C.

Key value for chemical safety assessment

Additional information

The pKa at 25°C is 6.54.