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Physical & Chemical properties

Partition coefficient

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partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
11 February - 9 April 2002
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
according to guideline
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
according to guideline
EU Method A.8 (Partition Coefficient - HPLC Method)
GLP compliance:
yes (incl. QA statement)
Type of method:
HPLC method
Partition coefficient type:
Specific details on test material used for the study:
- Batch n°: ZR027180PUG231
- Analytical purity: 99.3%
- Expiration date: 9 November 2006
- Storage condition: at room temperature, 10 to 30°C
Key result
log Pow
Partition coefficient:
20 °C
Remarks on result:
other: No temperature or pH value were reported but based on the use of references a standard temperature of 20°C and pH7 are assumed
The mobile phase for elution was MeOH 0.01M pH4 citrate buffer 75:25
Details on results:
The compound Imazalil 75SP eluted as a single peak with a retention time which was within the range of retention times of the calibration substances. Therefore the results of the estimation may be expected to be realistic, as the results were calculated by interpolation rather than extrapolation. It was possible to establish the calibration line with six different calibration compounds, three eluting before the test compound and three after.
There were only minimal differences between the replicates of retention times for each of the calibration and test substances, and between the two injection sequences. The resultant calculated values differed only to a small extent, therefore the results may be considered as acceptable for regulatory purposes.
The partition coefficient of Imazalil 75SP (Product ZR027180) was successfully evaluated using the HPLC simulation technique with a mobile phase of MeOH 0.01M pH4 citrate buffer 75:25. The test substance eluted as a single component exhibiting a retention time corresponding to a log Pow value of +3.31 and which was within a 95% confidence range of +3.2 to +3.4.
The partition coefficient of the test substance was determined to be log Pow value of +3.31, and which was within a 95% confidence range of +3.2 to + 3.4.

Description of key information

Based on a key study (K1, Bates, 2002) using the HPLC method according to EU method A.8 and OECD guideline 117, the partition coefficient (log Pow) of the test item was determined to be 3.31.

Key value for chemical safety assessment

Log Kow (Log Pow):
at the temperature of:
20 °C

Additional information