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EC number: 701-179-4 | CAS number: -
The acute oral toxicity was tested with the read across substance Rape oil, sulfonated, sodium salt (CAS 91081-16-2) in young Wistar rats. No mortality was observed. According to this result the LD50 (oral) was determined to be >2000 mg/kg bw. Furthermore, the acute dermal toxicity was tested with Octadecanoic acid, sulfo-, potassium salt up to a concentration of 2000 mg/kg bw. No mortality was observed. According to this result the LD50 (dermal) was determined to be >2000 mg/kg.
A read across approach was applied for acute oral toxicity using data of the similar Rape oil, sulfonated, sodium salt. This substance is considered to show similar toxicological properties as compared to the test item. After passage of the stomach, the glyceride is degraded to glycerin and sulfonated fatty acids, mainly sulfonated oleic acid. In terms, of acute oral toxicity, there should be difference to sulfonated octadecanoic acid.
The acute oral toxicity of the read across substance Rape oil, sulfonated, sodium salt (CAS 91081 -16 -2) was tested in young Wistar rats (breeder Winkelmann, Borchen). The test compound was administered by single gavage in aqua dest water as solvent and in an application volume of 10 mL kg body weight. Five rats were used per sex. Neither mortality effects nor any other abnormalities were observed in this study. According to this result the LD50 was determined to be >2000 mg/kg bw for male rats and for female rats. The substance is not acute oral toxic for rats.
Furthermore, the acute dermal toxicity was tested with Octadecanoic acid, sulfo-, potassium salt up to a concentration of 2000 mg/kg bw. No mortality was observed. According to this result the LD50 (dermal) was determined to be >2000 mg/kg.
Dangerous Substance Directive (67/548/EEC) The available study is considered reliable and suitable for classification purposes under Directive 67/548/EEC. As a result the substance is not considered to be classified for acute oral and dermal toxicity under Directive 67/548/EEC, as amended for the 31st time in Directive 2009/2/EG.
Classification, Labelling, and Packaging Regulation (EC) No 1272/2008 The available experimental test data are reliable and suitable for classification purposes under Regulation (EC) No 1272/2008.As a result the substance is not considered to be classified for acute oral and dermal toxicity under Regulation (EC) No 1272/2008, as amended for the sixth time in Regulation (EC) No 1297/2014.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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