Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Repeated dose toxicity: inhalation

Currently viewing:

Administrative data

Endpoint:
short-term repeated dose toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature

Data source

Reference
Title:
No information
Author:
Rusin, V.Y.: Gig. Truda Profzabol. (1958), 247-251|(published 1959);|cited in: TSCATS: OTS 0000937, Doc. ID. FYI-OTS-0794-0937,|Haskell Laboratory for E.I. Dupont de Nemours & Co., 1-30-84

Materials and methods

GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2,2'-dimethyl-2,2'-azodipropiononitrile
EC Number:
201-132-3
EC Name:
2,2'-dimethyl-2,2'-azodipropiononitrile
Cas Number:
78-67-1
Molecular formula:
C8H12N4
IUPAC Name:
2,2'-dimethyl-2,2'-azodipropiononitrile
Details on test material:
2,2'-azobisisobutyronitrile; no data on purity of the compound

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
inhalation: vapour
Duration of treatment / exposure:
10 days
Frequency of treatment:
2 h/d
Doses / concentrations
Remarks:
no data
No. of animals per sex per dose:
5
Control animals:
not specified
Details on study design:
- Post-exposure period: none

Results and discussion

Results of examinations

Description (incidence):
one rat died
Description (incidence and severity):
Morphological changes similar to those observed after intoxication with nitriles and cyanides were found.

Target system / organ toxicity

Critical effects observed:
not specified

Any other information on results incl. tables

Five rats were exposed to vapours produced by heating of the test substance to 70-80 degrees Centigrade. According to
the authors, HCN concentration did not exceed 1.4-1.6 mg/m3 (1.4-1.6x10E-3 mg/l). One rat died. Morphological changes similar to those observed after intoxication with nitriles and cyanides were found. Only secondary literature; no
further data.

Applicant's summary and conclusion